SPTLC1

Gene Symbol	SPTLC1
Entrez Gene	10558
Alt Symbol	HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI
Species	Human
Gene Type	protein-coding
Description	serine palmitoyltransferase, long chain base subunit 1
Other Description	LCB 1|SPT 1|long chain base biosynthesis protein 1|serine C-palmitoyltransferase|serine palmitoyltransferase 1|serine-palmitoyl-CoA transferase 1
Swissprots	A8K681 O15269 Q96IX6 Q5VWB4
Accessions	AAK29328 CCQ43355 EAW62804 EAW62805 EAW62806 O15269 AB209757 BAD92994 AF147304 AK098344 AK291546 BAF84235 AK299153 BAG61202 AK309775 BC007085 AAH07085 BC068537 AAH68537 DA305642 EC564300 Y08685 CAA69941 XM_011518138 XP_011516440 XM_011518139 XP_011516441 NM_001281303 NP_001268232 NM_006415 NP_006406 NM_178324 NP_847894
Function	Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. {ECO:0000269|PubMed:19416851}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Tissue Specificity	Widely expressed. Not detected in small intestine. {ECO:0000269|PubMed:17023427}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SPTLC1 protein fragment - ab132884 from Abcam Category Protein Source Wheat germ Species Human

SPTLC1 / HSN1 Antibody Blocking Peptide - LS-E16995 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPTLC1 / HSN1 Antibody Blocking Peptide - LS-E16996 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPTLC1 / HSN1 Antibody Blocking Peptide - LS-E6994 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPTLC1 / HSN1 Antibody Blocking Peptide - LS-E6995 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPTLC1 / HSN1 Antibody Blocking Peptide - LS-E31115 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SPTLC1 Recombinant Protein - H00010558-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SPTLC1 Peptide - P1148 from Novus Biologicals Category Peptide Species Human

SPTLC1 Peptide - P1147 from Novus Biologicals Category Peptide Species Human

SPTLC1-Antibody-C-term-Blocking-Peptide - BP2534b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPTLC1-Antibody-N-term-Blocking-Peptide - BP2534a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPTLC1 Blocking Peptide - 33R-3905 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SPTLC1 Blocking Peptide - 33R-2041 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SPTLC1 - H00010558-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SPTLC1 - H00010558-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SPTLC1 Control Peptide - AP05280CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

SPT1 Peptide - 6303P from ProSci Category Peptide Species Human

SPTLC1 fusion protein - ag7876 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SPTLC1 fusion protein - ag1162 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SPTLC1, His-tagged - SPTLC1-30887TH from Creative Biomart Category Protein Source E. coli

Recombinant Serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) - RPH138Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Serine Palmitoyltransferase, Long Chain Base Subunit 1 (SPTLC1) - RPH138Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human Serine palmitoyltransferase 1(SPTLC1) - CSB-YP022639HU CSB-EP022639HU CSB-BP022639HU CSB-MP022639HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SPTLC1 Peptide (OEEG01138) - OEEG01138 from Aviva Systems Biology Category Peptide Prices $150.00 Sizes 50 µg Species Human

SPTLC1 (transcript variant 1) - TP322985 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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