SPTLC1

Gene Symbol	SPTLC1
Entrez Gene	10558
Alt Symbol	HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI
Species	Human
Gene Type	protein-coding
Description	serine palmitoyltransferase, long chain base subunit 1
Other Description	LCB 1|SPT 1|long chain base biosynthesis protein 1|serine C-palmitoyltransferase|serine palmitoyltransferase 1|serine-palmitoyl-CoA transferase 1
Swissprots	A8K681 O15269 Q96IX6 Q5VWB4
Accessions	AAK29328 CCQ43355 EAW62804 EAW62805 EAW62806 O15269 AB209757 BAD92994 AF147304 AK098344 AK291546 BAF84235 AK299153 BAG61202 AK309775 BC007085 AAH07085 BC068537 AAH68537 DA305642 EC564300 Y08685 CAA69941 XM_011518138 XP_011516440 XM_011518139 XP_011516441 NM_001281303 NP_001268232 NM_006415 NP_006406 NM_178324 NP_847894
Function	Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. {ECO:0000269|PubMed:19416851}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Tissue Specificity	Widely expressed. Not detected in small intestine. {ECO:0000269|PubMed:17023427}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SPTLC1 - MBS1277479 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC007085

SPTLC1 - MBS1278383 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC068537

Human SPTLC1 cDNA clone(NM_178324.1) - CDFG011547 from Creative Biomart Species Human Accession NM_178324.1

Human SPTLC1 cDNA clone(NM_006415.2) - CDFH018583 from Creative Biomart Species Human Accession NM_006415.2

Human SPTLC1 ORF Clone(NM_006415.2) - CDCR292852 from Creative Biomart Species Human Accession NM_006415.2

Human SPTLC1 ORF Clone(NM_006415.2) - CDCR292853 from Creative Biomart Species Human Accession NM_006415.2

Human SPTLC1 ORF Clone(NM_006415.2) - CDCR292854 from Creative Biomart Species Human Accession NM_006415.2

Human SPTLC1 ORF Clone(NM_178324.1) - CDCR323155 from Creative Biomart Species Human Accession NM_178324.1

Human SPTLC1 ORF Clone(NM_178324.1) - CDCR323156 from Creative Biomart Species Human Accession NM_178324.1

human SPTLC1 ORF clone - CDCH085714 from Creative Biomart Species Human Accession NM_006415

human SPTLC1 ORF clone - CDCH085715 from Creative Biomart Species Human Accession NM_006415

human SPTLC1 ORF clone - CDCH085716 from Creative Biomart Species Human Accession NM_006415

human SPTLC1 ORF clone - CDCH085717 from Creative Biomart Species Human Accession NM_006415

Human SPTLC1 ORF Clone(NM_006415.2) - CDCL176971 from Creative Biomart Species Human Accession NM_006415.2

Human SPTLC1 ORF Clone(NM_006415.2) - CDCR292852 from Creative biogene Species Human

human SPTLC1 ORF clone (NM_178324.1) - CDCH085716 from Creative biogene Species Human

Human SPTLC1 ORF Clone (BC007085) - CDCS412725 from Creative biogene Species Human Accession O15269

Human SPTLC1 ORF Clone (BC068537) - CDCS412726 from Creative biogene Species Human Accession O15269

Human SPTLC1 cDNA Clone(NM_178324.1) - CDFG011547 from Creative biogene Species Human

Human SPTLC1 cDNA Clone(NM_006415.2) - CDFH018583 from Creative biogene Species Human

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