SPTLC1

Gene Symbol SPTLC1
Entrez Gene 10558
Alt Symbol HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI
Species Human
Gene Type protein-coding
Description serine palmitoyltransferase, long chain base subunit 1
Other Description LCB 1|SPT 1|long chain base biosynthesis protein 1|serine C-palmitoyltransferase|serine palmitoyltransferase 1|serine-palmitoyl-CoA transferase 1
Swissprots A8K681 O15269 Q96IX6 Q5VWB4
Accessions AAK29328 CCQ43355 EAW62804 EAW62805 EAW62806 O15269 AB209757 BAD92994 AF147304 AK098344 AK291546 BAF84235 AK299153 BAG61202 AK309775 BC007085 AAH07085 BC068537 AAH68537 DA305642 EC564300 Y08685 CAA69941 XM_011518138 XP_011516440 XM_011518139 XP_011516441 NM_001281303 NP_001268232 NM_006415 NP_006406 NM_178324 NP_847894
Function Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. {ECO:0000269|PubMed:19416851}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed. Not detected in small intestine. {ECO:0000269|PubMed:17023427}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

SPTLC1 (H-1) - sc-374143 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPTLC1 (H-1): sc-374143. Western blot analysis of SPTLC1 expression in 293T whole cell lysate (A) and human liver tissue extract (B).

SPTLC1 (H-300) - sc-32916 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SPTLC1 (H-300): sc-32916. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.

SPTLC1 (N-17) - sc-27495 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPTLC1 (E-17) - sc-27497 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPTLC1 (49) - sc-136076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
SPTLC1 (49): sc-136076. Western blot analysis of SPTLC1 expression in rat kidney tissue extract.

Anti-SPTLC1 antibody - ab112569 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SPTLC1 antibody (ab112569) at 1 µg/mlLane 1 : Human lung tissue lysate Lane 2 : Human lung tissue lysate with blocking peptideLysates/proteins at 15 µg per lane.

Anti-SPTLC1 antibody - ab100930 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SPTLC1 antibody (ab100930) at 1 µg/ml + Brain (Human) Tissue Lysate - adult normal tissue (ab29466) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-SPTLC1 / HSN1 Antibody (C-Terminus, Biotin) - LS-C282946 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPTLC1 / HSN1 Antibody (C-Terminus, FITC) - LS-C282947 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPTLC1 / HSN1 Antibody (C-Terminus, Azide-free, HRP) - LS-C282948 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPTLC1 / HSN1 Antibody (C-Terminus, PE) - LS-C282949 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPTLC1 / HSN1 Antibody (aa423-473) - LS-C290087 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SPTLC1 / HSN1 Antibody (aa50-100) - LS-C290086 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SPTLC1 / HSN1 Antibody (C-Terminus) - LS-C330671 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPTLC1 / HSN1 Antibody - LS-C140566 from LifeSpan Bioscience

Prices $460.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal
Left: IHC of normal human lung tissue with serine palmitoyltransferase 1 antibody (LS-C140566) at 15 ug/ml. Right: Western blot on human kidney lysate (10 ug/lane) using anti Serine palmitoyltransferase 1 antibody (LS-C140566) at 1 ug/ml. Blot was developed using anti rabbit HRP at 1:75k and Pierce Supersignal West Femto. Exposure was 2 minutes.

Anti-SPTLC1 / HSN1 Antibody (C-Terminus) - LS-C144369 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of SPT1 in human lung tissue with SPT1 antibody at 5 ug/ml.

Anti-SPTLC1 / HSN1 Antibody - LS-C334923 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using SPTLC1 antibody.

Anti-SPTLC1 / HSN1 Antibody (aa138-154) - LS-C312924 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SPTLC1 / HSN1 antibody. IHC(P): Human Breast Cancer Tissue.

Anti-SPTLC1 / HSN1 Antibody (aa26-57) - LS-C98506 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of hSPTLC1-S41 in 293, HeLa, K562 cell line and mouse liver tissue lysates (35 ug/lane). SPTLC1 (arrow) was detected using the purified antibody.

Anti-SPTLC1 / HSN1 Antibody (aa216-265) - LS-C102242 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SPTLC1 antibody LS-C102242 Western blot of Fetal Brain lysate.

Anti-SPTLC1 / HSN1 Antibody (C-Terminus, AP) - LS-C282937 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPTLC1 / HSN1 Antibody (C-Terminus, APC) - LS-C282938 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPTLC1 / HSN1 Antibody (C-Terminus, Biotin) - LS-C282940 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPTLC1 / HSN1 Antibody - LS-C26930 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot on human kidney lysate (10 ug/lane) using anti Serine palmitoyltransferase 1 antibody (LS-C26930) at 1 ug/ml. Blot was developed using anti rabbit HRP at 1:75k and Pierce Supersignal West Femto. Exposure was 2 minutes.

Anti-SPTLC1 / HSN1 Antibody (C-Terminus, FITC) - LS-C282941 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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