| Gene Symbol | SPTLC1 |
|---|---|
| Entrez Gene | 10558 |
| Alt Symbol | HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI |
| Species | Human |
| Gene Type | protein-coding |
| Description | serine palmitoyltransferase, long chain base subunit 1 |
| Other Description | LCB 1|SPT 1|long chain base biosynthesis protein 1|serine C-palmitoyltransferase|serine palmitoyltransferase 1|serine-palmitoyl-CoA transferase 1 |
| Swissprots | A8K681 O15269 Q96IX6 Q5VWB4 |
| Accessions | AAK29328 CCQ43355 EAW62804 EAW62805 EAW62806 O15269 AB209757 BAD92994 AF147304 AK098344 AK291546 BAF84235 AK299153 BAG61202 AK309775 BC007085 AAH07085 BC068537 AAH68537 DA305642 EC564300 Y08685 CAA69941 XM_011518138 XP_011516440 XM_011518139 XP_011516441 NM_001281303 NP_001268232 NM_006415 NP_006406 NM_178324 NP_847894 |
| Function | Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. {ECO:0000269|PubMed:19416851}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Not detected in small intestine. {ECO:0000269|PubMed:17023427}. |
| Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |