PROK1
| Gene Symbol | PROK1 |
|---|---|
| Entrez Gene | 84432 |
| Alt Symbol | EGVEGF, PK1, PRK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | prokineticin 1 |
| Other Description | EG-VEGF|black mamba toxin-related protein|endocrine-gland-derived vascular endothelial growth factor|mambakine|prokineticin-1 |
| Swissprots | Q5VWD4 P58294 Q8TC69 |
| Accessions | CAI59103 CAN87427 EAW56449 EAW56450 P58294 AF333024 AAK49918 AY029225 AAK33111 AY358683 AAQ89046 BC025399 AAH25399 BM544315 DQ891570 ABM82496 DQ894763 ABM85689 NM_032414 NP_115790 |
| Function | Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. {ECO:0000269|PubMed:11259612, ECO:0000269|PubMed:11528470, ECO:0000269|PubMed:15292351, ECO:0000269|PubMed:17289879, ECO:0000269|PubMed:18339712}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta. {ECO:0000269|PubMed:11528470, ECO:0000269|PubMed:15292351, ECO:0000269|PubMed:18339712}. |
EG-VEGF CRISPR/Cas9 KO Plasmid (h) - sc-404774 from Santa Cruz Biotechnology
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EG-VEGF HDR Plasmid (h) - sc-404774-HDR from Santa Cruz Biotechnology
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EG-VEGF Double Nickase Plasmid (h) - sc-404774-NIC from Santa Cruz Biotechnology
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EG-VEGF Double Nickase Plasmid (h2) - sc-404774-NIC-2 from Santa Cruz Biotechnology
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EG-VEGF CRISPR Activation Plasmid (h) - sc-404774-ACT from Santa Cruz Biotechnology
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EG-VEGF CRISPR Activation Plasmid (h2) - sc-404774-ACT-2 from Santa Cruz Biotechnology
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EG-VEGF Lentiviral Activation Particles (h) - sc-404774-LAC from Santa Cruz Biotechnology
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EG-VEGF Lentiviral Activation Particles (h2) - sc-404774-LAC-2 from Santa Cruz Biotechnology
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EG-VEGF siRNA (h) - sc-45392 from Santa Cruz Biotechnology
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EG-VEGF shRNA Plasmid (h) - sc-45392-SH from Santa Cruz Biotechnology
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EG-VEGF shRNA (h) Lentiviral Particles - sc-45392-V from Santa Cruz Biotechnology
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EG-VEGF/PK1 RNAi - H00084432-R01 from Novus Biologicals
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MISSION® esiRNA - EHU050351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17456 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17456 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07713 from Sigma-Aldrich
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PROK1 siRNA (Human) - CRJ3467 from Cohesion Biosciences
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shRNA set against Human PROK1 (NM_032414.2) - SHH383496 from Creative biogene
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shRNA set against Human PROK1(NM_032414.2) - SHR141716 from Creative biogene
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Human PROK1 siRNA - orb273968 from Biorbyt
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PROK1 shRNA Plasmid (Human) - CHJ3467 from Cohesion Biosciences
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PROK1 miRNA 3'UTR clone - MiUTR1H-08307 from Creative biogene
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