| Gene Symbol |
PROK1
|
| Entrez Gene |
84432
|
| Alt Symbol |
EGVEGF, PK1, PRK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prokineticin 1
|
| Other Description |
EG-VEGF|black mamba toxin-related protein|endocrine-gland-derived vascular endothelial growth factor|mambakine|prokineticin-1
|
| Swissprots |
Q5VWD4 P58294 Q8TC69
|
| Accessions |
CAI59103 CAN87427 EAW56449 EAW56450 P58294 AF333024 AAK49918 AY029225 AAK33111 AY358683 AAQ89046 BC025399 AAH25399 BM544315 DQ891570 ABM82496 DQ894763 ABM85689 NM_032414 NP_115790
|
| Function |
Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. {ECO:0000269|PubMed:11259612, ECO:0000269|PubMed:11528470, ECO:0000269|PubMed:15292351, ECO:0000269|PubMed:17289879, ECO:0000269|PubMed:18339712}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta. {ECO:0000269|PubMed:11528470, ECO:0000269|PubMed:15292351, ECO:0000269|PubMed:18339712}.
|
