| Gene Symbol | CD86 |
|---|---|
| Entrez Gene | 942 |
| Alt Symbol | B7-2, B7.2, B70, CD28LG2, LAB72 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD86 molecule |
| Other Description | B-lymphocyte activation antigen B7-2|BU63|CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)|CTLA-4 counter-receptor B7.2|FUN-1|T-lymphocyte activation antigen CD86 |
| Swissprots | E7ETN5 Q7M4L5 Q6GTS4 E9PC27 B7Z702 A0N0P0 B7Z2F3 P42081 Q13655 Q6FHB1 |
| Accessions | AAA86473 ABK41931 CDM22279 EAW79493 EAW79494 P42081 AK291497 BAF84186 AK294663 BAH11839 AK301237 BAH13438 AK313103 BAG35926 AK316203 BAH14574 BC040261 AAH40261 BX093060 CD705810 CR541844 CAG46642 DA619360 DQ890617 ABM92234 DQ893787 ABM84713 L25259 AAA58389 U04343 AAB03814 NM_001206924 NP_001193853 NM_001206925 NP_001193854 NM_006889 NP_008820 NM_175862 NP_787058 NM_176892 NP_795711 |
| Function | Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed by activated B-lymphocytes and monocytes. |
| Top Pathways | Type I diabetes mellitus, Graft-versus-host disease, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production |
B7-2 CRISPR/Cas9 KO Plasmid (h) - sc-418032 from Santa Cruz Biotechnology
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B7-2 HDR Plasmid (h) - sc-418032-HDR from Santa Cruz Biotechnology
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B7-2 Double Nickase Plasmid (h) - sc-418032-NIC from Santa Cruz Biotechnology
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B7-2 Double Nickase Plasmid (h2) - sc-418032-NIC-2 from Santa Cruz Biotechnology
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B7-2 CRISPR Activation Plasmid (h) - sc-418032-ACT from Santa Cruz Biotechnology
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B7-2 CRISPR Activation Plasmid (h2) - sc-418032-ACT-2 from Santa Cruz Biotechnology
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B7-2 Lentiviral Activation Particles (h) - sc-418032-LAC from Santa Cruz Biotechnology
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B7-2 Lentiviral Activation Particles (h2) - sc-418032-LAC-2 from Santa Cruz Biotechnology
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B7-2 siRNA (h) - sc-29774 from Santa Cruz Biotechnology
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B7-2 shRNA Plasmid (h) - sc-29774-SH from Santa Cruz Biotechnology
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B7-2 shRNA (h) Lentiviral Particles - sc-29774-V from Santa Cruz Biotechnology
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B7-2/CD86 RNAi - H00000942-R04 from Novus Biologicals
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B7-2/CD86 RNAi - H00000942-R03 from Novus Biologicals
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MISSION® esiRNA - EHU083111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5757 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5757 from Sigma-Aldrich
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CD86 siRNA (Human) - CRH0664 from Cohesion Biosciences
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CD86 - MBS8211054 from MyBioSource
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shRNA set against Human CD86 (NM_006889.4) - SHH259437 from Creative biogene
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CD86 shRNA Plasmid (Human) - CHH0664 from Cohesion Biosciences
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CD86 miRNA 3'UTR clone - MiUTR1H-01914 from Creative biogene
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CD86 miRNA 3'UTR clone - MiUTR1H-01915 from Creative biogene
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CD86 miRNA 3'UTR clone - MiUTR3H-03804 from Creative biogene
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CD86 miRNA 3'UTR clone - MiUTR3H-03805 from Creative biogene
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