CD86

Gene Symbol	CD86
Entrez Gene	942
Alt Symbol	B7-2, B7.2, B70, CD28LG2, LAB72
Species	Human
Gene Type	protein-coding
Description	CD86 molecule
Other Description	B-lymphocyte activation antigen B7-2|BU63|CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)|CTLA-4 counter-receptor B7.2|FUN-1|T-lymphocyte activation antigen CD86
Swissprots	E7ETN5 Q7M4L5 Q6GTS4 E9PC27 B7Z702 A0N0P0 B7Z2F3 P42081 Q13655 Q6FHB1
Accessions	AAA86473 ABK41931 CDM22279 EAW79493 EAW79494 P42081 AK291497 BAF84186 AK294663 BAH11839 AK301237 BAH13438 AK313103 BAG35926 AK316203 BAH14574 BC040261 AAH40261 BX093060 CD705810 CR541844 CAG46642 DA619360 DQ890617 ABM92234 DQ893787 ABM84713 L25259 AAA58389 U04343 AAB03814 NM_001206924 NP_001193853 NM_001206925 NP_001193854 NM_006889 NP_008820 NM_175862 NP_787058 NM_176892 NP_795711
Function	Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed by activated B-lymphocytes and monocytes.
Top Pathways	Type I diabetes mellitus, Graft-versus-host disease, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD86-Over-expression-Lysate - LY12362a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CD86 293T Cell Transient Overexpression Lysate(Denatured) - H00000942-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CD86 293 Cell Lysate - 403095 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

B7-2/CD86 Overexpression Lysate (Denatured) - H00000942-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

B7-2/CD86 Overexpression Lysate (Native) - NBP2-07567 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

B7-2 (h): 293T Lysate - sc-114494 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

B7-2 (h2): 293T Lysate - sc-175289 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

B7-2 (h3): 293T Lysate - sc-175291 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CD86 Over-expression Lysate Product - GWB-1F8FA3 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Cynomolgus CD86 / B7-2 HEK293 Cell Lysate (WB positive control) - 90270-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Cynomolgus CD86 / B7-2 HEK293 Cell Lysate (WB positive control) - 90270-C02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human CD86 / B7-2 HEK293 Cell Lysate (WB positive control) - 10699-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CD86 / B7-2 HEK293 Cell Lysate (WB positive control) - 10699-H03HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CD86 Human Cells Transfected Lysate (positive control) (denatured) - orb172783 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human CD86 Human Cells Transfected Lysate (positive control) (denatured) - orb173214 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human CD86 Knockdown Stable Cell Line - CSC-DC002778 from Creative biogene Category Cell Line Species Human

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