CD86

Gene Symbol	CD86
Entrez Gene	942
Alt Symbol	B7-2, B7.2, B70, CD28LG2, LAB72
Species	Human
Gene Type	protein-coding
Description	CD86 molecule
Other Description	B-lymphocyte activation antigen B7-2|BU63|CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)|CTLA-4 counter-receptor B7.2|FUN-1|T-lymphocyte activation antigen CD86
Swissprots	E7ETN5 Q7M4L5 Q6GTS4 E9PC27 B7Z702 A0N0P0 B7Z2F3 P42081 Q13655 Q6FHB1
Accessions	AAA86473 ABK41931 CDM22279 EAW79493 EAW79494 P42081 AK291497 BAF84186 AK294663 BAH11839 AK301237 BAH13438 AK313103 BAG35926 AK316203 BAH14574 BC040261 AAH40261 BX093060 CD705810 CR541844 CAG46642 DA619360 DQ890617 ABM92234 DQ893787 ABM84713 L25259 AAA58389 U04343 AAB03814 NM_001206924 NP_001193853 NM_001206925 NP_001193854 NM_006889 NP_008820 NM_175862 NP_787058 NM_176892 NP_795711
Function	Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed by activated B-lymphocytes and monocytes.
Top Pathways	Type I diabetes mellitus, Graft-versus-host disease, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-CD86-cDNA-Clone - DC07341 from Abgent, a WuXi AppTec company Prices $444.15 Sizes 10 µg Species Human Accession BC040261

Mouse B7-2/CD86 (NP_062261) VersaClone cDNA - RDC1181 from R&D Systems Prices $199.00 Sizes 10 µg Species Mouse

Human B7-2/CD86 (NP_787058) VersaClone cDNA - RDC0693 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

CD86 - MBS1267487 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC040261

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone in cloning vector - HG10699-G from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10699-ACR from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid - HG10699-UT from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10699-ACG from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG10699-NH from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10699-NF from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10699-NM from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10699-CY from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10699-CF from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10699-CM from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10699-NY from Sino Biological Species Human

Human CD86/B7-2 transcript variant 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG10699-CH from Sino Biological Species Human

B7-2/CD86 - CL01192H01 from Elabscience Species Human Accession NM_001206924.1

B7-2/CD86 - CL01192H02 from Elabscience Species Human Accession NM_001206925.1

B7-2/CD86 - CL01192H03 from Elabscience Species Human Accession NM_006889.4

Human CD86 ORF clone (NM_001206924.1) - CDCR044550 from Creative biogene Species Human

Human CD86 ORF clone (NM_001206925.1) - CDCR044552 from Creative biogene Species Human

Human CD86 ORF clone (NM_176892.1) - CDCR044554 from Creative biogene Species Human

Human CD86 ORF Clone (BC040261) - CDCS409678 from Creative biogene Species Human Accession P42081

Human B7-2 / CD86 transcript variant 2 Gene cDNA Clone - orb141970 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Rat B7-2/CD86 (NP_064466) VersaClone cDNA - RDC1770 from R&D Systems Prices $199.00 Sizes 10 µg Species Rat

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