DHDDS

Gene Symbol DHDDS
Entrez Gene 79947
Alt Symbol CIT, CPT, DS, HDS, RP59
Species Human
Gene Type protein-coding
Description dehydrodolichyl diphosphate synthase
Other Description cis-IPTase|cis-isoprenyltransferase|cis-prenyl transferase|dedol-PP synthase|dehydrodolichyl diphosphate syntase complex subunit DHDDS|epididymis tissue protein Li 189m
Swissprots Q5T0A4 E9KL43 D3DPK7 Q8NE90 D3DPK9 Q86SQ9 Q9BTK3 D3DPK8 B7ZB20 Q9BTG5 B7Z4B9 Q9H905
Accessions CAR80515 CAR80538 CBX83986 CBX84009 EAX07806 EAX07807 EAX07808 EAX07809 EAX07810 EAX07811 EAX07812 Q86SQ9 AB090852 BAC57588 AK023164 BAB14439 AK297134 BAH12505 AK308187 AK316485 BAH14856 AW294595 BC003643 AAH03643 BC004117 AAH04117 BC034152 AAH34152 BQ028814 BX648507 GU727641 ADU87642 JF432680 ADZ15897 XM_006710912 XP_006710975 XM_006710913 XP_006710976 XM_006710914 XP_006710977 XM_006710915 XP_006710978 XM_006710916 XP_006710979 XM_006710917 XP_006710980 XM_006710918 XP_006710981 XM_006710919 XP_006710982 XM_011542183 XP_011540485 XM_011542184 XP_011540486 XM_011542185 XP_011540487 XM_011542186 XP_011540488 NM_001243564 NP_001230493 NM_001243565 NP_001230494 NM_024887 NP_079163 NM_205861 NP_995583
Function With DHDDS, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. {ECO:0000269|PubMed:25066056, ECO:0000303|PubMed:21572394}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14652022}; Peripheral membrane protein {ECO:0000269|PubMed:14652022}. Note=colocalizes with calnexin.
Tissue Specificity Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level). Slightly expressed in heart, spleen and thymus. {ECO:0000269|PubMed:20736409}.
Top Pathways Terpenoid backbone biosynthesis

DHDDS (C-18) - sc-242575 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DHDDS (S-18) - sc-242574 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Dehydrodolichyl Diphosphate Synthase antibody - ab67447 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Dehydrodolichyl Diphosphate Synthase antibody (ab67447) at 1/500 dilutionLane 1 : Transfected 293T cell lysateLane 2 : non Transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-HDS / DHDDS Antibody - LS-C307236 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HDS / DHDDS Antibody - LS-C310123 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HDS / DHDDS Antibody (aa36-85) - LS-C102326 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DHDDS antibody LS-C102326 Western blot of Placenta lysate.

Anti-HDS / DHDDS Antibody (aa218-267) - LS-C201557 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human 293T. DHDDS antibody dilution 1.0 ug/ml.

Dehydrodolichyl Diphosphate Synthase Antibody - NBP1-87964 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Dehydrodolichyl Diphosphate Synthase Antibody [NBP1-87964] - Staining of human epididymis shows strong positivity in glandular cells.

Dehydrodolichyl Diphosphate Synthase Antibody - NBP1-84975 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Dehydrodolichyl Diphosphate Synthase Antibody [NBP1-84975] - Analysis in human cell line HeLa.

Dehydrodolichyl Diphosphate Synthase Antibody - NBP1-55231 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Dehydrodolichyl Diphosphate Synthase Antibody [NBP1-55231] - Human Placenta lysate, concentration 0.2-1 ug/ml.

Citron Kinase Antibody - NBP1-88050 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Citron Kinase Antibody [NBP1-88050] - Staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells.

Dehydrodolichyl Diphosphate Synthase Antibody - H00079947-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Dehydrodolichyl Diphosphate Synthase Antibody - H00079947-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Dehydrodolichyl Diphosphate Synthase Antibody [H00079947-B01] - analysis of DHDDS expression in transfected 293T cell line by DHDDS MaxPab polyclonal antibody (B01). Lane 1: DHDDS transfected lysate (34.30 KDa). Lane 2: Non-transfected lysate.

Dehydrodolichyl Diphosphate Synthase Antibody - H00079947-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DHDDS antibody produced in rabbit - HPA026721 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DHDDS: <B>Cat. No. HPA026721</B>: Immunohistochemical staining of human stomach shows strong cytoplasmic and membranous positivity in glandular cells.

Anti-DHDDS antibody produced in rabbit - HPA026727 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DHDDS: <B>Cat. No. HPA026727</B>: Immunohistochemical staining of human epididymis shows strong positivity in glandular cells.

Anti-DHDDS (156-170) antibody produced in rabbit - SAB1102143 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human DHDDS was separated on SDS-PAGE, blotted with Anti-DHDDS (156-170) (<B>Cat. No. SAB1102143</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000

Anti-DHDDS antibody produced in rabbit - SAB2100572 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DHDDS: <B>Cat. No.SAB2100572</B>: DHDDS in Placenta tissue lysate with DHDDS antibody at 1.0 μg/mL.

Anti-DHDDS antibody produced in mouse - SAB1407995 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DHDDS: <B>Cat. No. SAB1407995</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~32.3 kDa using DHDDS transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

DHDDS antibody - N-terminal region (ARP48925_P050) - ARP48925_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DHDDS Antibody - C-terminal region (ARP48926_P050) - ARP48926_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DHDDS antibody, N-term - GTX46164 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-DHDDS antibody, N-term used in Western blot. GTX46164

DHDDS antibody - 70R-16816 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti -CIT (Citron Rho-interacting Kinase, CRIK, STK21, Serine/Threonine Protein Kinase 21) - 210154 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -DHDDS (Dehydrodolichyl Diphosphate Synthase, DS, CIT, CPT, HDS, RP59) - 210456 from USBiological Life Science

Host Rabbit
Clonality Polyclonal
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