DHDDS

Gene Symbol	DHDDS
Entrez Gene	79947
Alt Symbol	CIT, CPT, DS, HDS, RP59
Species	Human
Gene Type	protein-coding
Description	dehydrodolichyl diphosphate synthase
Other Description	cis-IPTase|cis-isoprenyltransferase|cis-prenyl transferase|dedol-PP synthase|dehydrodolichyl diphosphate syntase complex subunit DHDDS|epididymis tissue protein Li 189m
Swissprots	Q5T0A4 E9KL43 D3DPK7 Q8NE90 D3DPK9 Q86SQ9 Q9BTK3 D3DPK8 B7ZB20 Q9BTG5 B7Z4B9 Q9H905
Accessions	CAR80515 CAR80538 CBX83986 CBX84009 EAX07806 EAX07807 EAX07808 EAX07809 EAX07810 EAX07811 EAX07812 Q86SQ9 AB090852 BAC57588 AK023164 BAB14439 AK297134 BAH12505 AK308187 AK316485 BAH14856 AW294595 BC003643 AAH03643 BC004117 AAH04117 BC034152 AAH34152 BQ028814 BX648507 GU727641 ADU87642 JF432680 ADZ15897 XM_006710912 XP_006710975 XM_006710913 XP_006710976 XM_006710914 XP_006710977 XM_006710915 XP_006710978 XM_006710916 XP_006710979 XM_006710917 XP_006710980 XM_006710918 XP_006710981 XM_006710919 XP_006710982 XM_011542183 XP_011540485 XM_011542184 XP_011540486 XM_011542185 XP_011540487 XM_011542186 XP_011540488 NM_001243564 NP_001230493 NM_001243565 NP_001230494 NM_024887 NP_079163 NM_205861 NP_995583
Function	With DHDDS, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. {ECO:0000269|PubMed:25066056, ECO:0000303|PubMed:21572394}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:14652022}; Peripheral membrane protein {ECO:0000269|PubMed:14652022}. Note=colocalizes with calnexin.
Tissue Specificity	Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level). Slightly expressed in heart, spleen and thymus. {ECO:0000269|PubMed:20736409}.
Top Pathways	Terpenoid backbone biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Citron Rho-interacting kinase (CIT), Human, ELISA Kit - E01C1734 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

DHDDS (Human) IP-WB Antibody Pair - H00079947-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human Cit ELISA Kit - HC0050 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

cit, ELISA Kit - MBS9313502 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

dehydrodolichyl diphosphate synthase, ELISA Kit - MBS9327814 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Citrulline ELISA - E01C0043 from BlueGene Biotech Category ELISA Kit Sensitivity 1.0 pmol/mL

Human CIT ELISA Kit - E009496 from Biobool Category ELISA Kit Sensitivity 1.0 ng/mL.

Human DHDDS ELISA Kit - E011549 from Biobool Category ELISA Kit

Human CIT ELISA Kit - E080463 from Biobool Category ELISA Kit

Human Cit ELISA Kit - EHC0050 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Human Dehydrodolichyl diphosphate synthase (DHDDS) ELISA Kit - AE47345HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t

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