DHDDS

Gene Symbol DHDDS
Entrez Gene 79947
Alt Symbol CIT, CPT, DS, HDS, RP59
Species Human
Gene Type protein-coding
Description dehydrodolichyl diphosphate synthase
Other Description cis-IPTase|cis-isoprenyltransferase|cis-prenyl transferase|dedol-PP synthase|dehydrodolichyl diphosphate syntase complex subunit DHDDS|epididymis tissue protein Li 189m
Swissprots Q5T0A4 E9KL43 D3DPK7 Q8NE90 D3DPK9 Q86SQ9 Q9BTK3 D3DPK8 B7ZB20 Q9BTG5 B7Z4B9 Q9H905
Accessions CAR80515 CAR80538 CBX83986 CBX84009 EAX07806 EAX07807 EAX07808 EAX07809 EAX07810 EAX07811 EAX07812 Q86SQ9 AB090852 BAC57588 AK023164 BAB14439 AK297134 BAH12505 AK308187 AK316485 BAH14856 AW294595 BC003643 AAH03643 BC004117 AAH04117 BC034152 AAH34152 BQ028814 BX648507 GU727641 ADU87642 JF432680 ADZ15897 XM_006710912 XP_006710975 XM_006710913 XP_006710976 XM_006710914 XP_006710977 XM_006710915 XP_006710978 XM_006710916 XP_006710979 XM_006710917 XP_006710980 XM_006710918 XP_006710981 XM_006710919 XP_006710982 XM_011542183 XP_011540485 XM_011542184 XP_011540486 XM_011542185 XP_011540487 XM_011542186 XP_011540488 NM_001243564 NP_001230493 NM_001243565 NP_001230494 NM_024887 NP_079163 NM_205861 NP_995583
Function With DHDDS, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. {ECO:0000269|PubMed:25066056, ECO:0000303|PubMed:21572394}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14652022}; Peripheral membrane protein {ECO:0000269|PubMed:14652022}. Note=colocalizes with calnexin.
Tissue Specificity Expressed at high levels in testis and kidney. Expressed in epididymis (at protein level). Slightly expressed in heart, spleen and thymus. {ECO:0000269|PubMed:20736409}.
Top Pathways Terpenoid backbone biosynthesis

DHDDS CRISPR/Cas9 KO Plasmid (h) - sc-409331 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHDDS HDR Plasmid (h) - sc-409331-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHDDS Double Nickase Plasmid (h) - sc-409331-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHDDS Double Nickase Plasmid (h2) - sc-409331-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHDDS CRISPR Activation Plasmid (h) - sc-409331-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHDDS CRISPR Activation Plasmid (h2) - sc-409331-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHDDS Lentiviral Activation Particles (h) - sc-409331-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHDDS Lentiviral Activation Particles (h2) - sc-409331-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHDDS siRNA (h) - sc-88357 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DHDDS shRNA Plasmid (h) - sc-88357-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DHDDS shRNA (h) Lentiviral Particles - sc-88357-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Citron RNAi - H00011113-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU073801 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7191 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7191 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DHDDS siRNA (Human) - CRJ2684 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DHDDS - MBS8211067 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DHDDS (NM_024887.3) - SHH277589 from Creative biogene

Category siRNA
Species Reactivities Human

DHDDS shRNA Plasmid (Human) - CHJ2684 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DHDDS miRNA 3'UTR clone - MiUTR4H-TG02706 from Creative biogene

Species Reactivities Human
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