| Gene Symbol |
YY1
|
| Entrez Gene |
7528
|
| Alt Symbol |
DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
YY1 transcription factor
|
| Other Description |
INO80 complex subunit S|YY-1|Yin and Yang 1 protein|delta transcription factor|transcriptional repressor protein YY1
|
| Swissprots |
P25490 Q14935
|
| Accessions |
EAW81689 EAW81690 P25490 AF147416 AK025731 AK026497 BC014138 BC020324 BC037308 AAH37308 BC065366 AAH65366 BX647456 DA234524 DQ891638 ABM82564 EU176600 ABW03401 M76541 AAA59926 M77698 AAA59467 Z14077 CAA78455 NM_003403 NP_003394
|
| Function |
Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presenc
|
| Subcellular Location |
Nucleus matrix {ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:23385818, ECO:0000269|PubMed:9493912}. Note=Associated with the nuclear matrix.
|