CENPC
| Gene Symbol | CENPC |
|---|---|
| Entrez Gene | 1060 |
| Alt Symbol | CENP-C, CENPC1, MIF2, hcp-4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | centromere protein C |
| Other Description | CENP-C 1|centromere autoantigen C|centromere autoantigen C1|centromere protein C 1|interphase centromere complex protein 7 |
| Swissprots | Q8IW27 Q03188 Q9P0M5 Q6PIR0 |
| Accessions | AAF73191 EAX05545 EAX05546 Q03188 AK307928 AK308170 AK308214 AK309437 BC030695 AAH30695 BC041117 AAH41117 BX648166 CD710556 M95724 AAA51974 XM_006714064 XP_006714127 XM_006714065 XP_006714128 XM_011531541 XP_011529843 XM_011531542 XP_011529844 XR_245245 XR_938676 NM_001812 NP_001803 |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:17651496}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. Note=Localizes exclusively in the kinetochore domain of centromeres. {ECO:0000269|PubMed:21529714}. |
Human CENPC full length protein - ab152272 from Abcam
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Human CENPC peptide - ab33339 from Abcam
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CENPC / CENP-C Antibody Blocking Peptide - LS-E70 from LifeSpan Bioscience
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CENPC / CENP-C Antibody Blocking Peptide - LS-E4019 from LifeSpan Bioscience
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Recombinant Human CENPC Protein - H00001060-P01 from Novus Biologicals
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CENPC1-Antibody-Center-Blocking-peptide - BP10142c from Abgent, a WuXi AppTec company
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CENPC1-Antibody-Center-Blocking-Peptide - BP16246c from Abgent, a WuXi AppTec company
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CENP-C - H00001060-P01 from Acris Antibodies
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CENPC1 fusion protein - Ag5523 from Proteintech Group
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CENPC1 fusion protein - ag5735 from Proteintech Group
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Recombinant Human CENPC1, GST-tagged - CENPC1-11094H from Creative Biomart
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CENPC1 Antibody - SH-A11002 from Novatein Biosciences
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CENPC1 Peptide, Human - M34GP02965H from Creative Peptides
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CENPC Recombinant Protein Antigen - NBP2-55474PEP from Novus Biologicals
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