| Gene Symbol |
CENPC
|
| Entrez Gene |
1060
|
| Alt Symbol |
CENP-C, CENPC1, MIF2, hcp-4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centromere protein C
|
| Other Description |
CENP-C 1|centromere autoantigen C|centromere autoantigen C1|centromere protein C 1|interphase centromere complex protein 7
|
| Swissprots |
Q8IW27 Q03188 Q9P0M5 Q6PIR0
|
| Accessions |
AAF73191 EAX05545 EAX05546 Q03188 AK307928 AK308170 AK308214 AK309437 BC030695 AAH30695 BC041117 AAH41117 BX648166 CD710556 M95724 AAA51974 XM_006714064 XP_006714127 XM_006714065 XP_006714128 XM_011531541 XP_011529843 XM_011531542 XP_011529844 XR_245245 XR_938676 NM_001812 NP_001803
|
| Function |
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17651496}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. Note=Localizes exclusively in the kinetochore domain of centromeres. {ECO:0000269|PubMed:21529714}.
|