PPP1R10

Gene Symbol PPP1R10
Entrez Gene 5514
Alt Symbol CAT53, FB19, PNUTS, PP1R10, R111, p99
Species Human
Gene Type protein-coding
Description protein phosphatase 1, regulatory subunit 10
Other Description HLA-C associated transcript 53|MHC class I region proline-rich protein CAT53|PP1-binding protein of 114 kDa|phosphatase 1 nuclear targeting subunit|protein phosphatase 1, regulatory (inhibitor) subunit 10|serine/threonine-protein phosphatase 1 regulatory subunit 10
Swissprots Q96QC0 O00405
Accessions BAB63324 BAC54929 BAE78613 BAF31264 EAX03303 Q96QC0 AJ544537 CAD67521 AK307406 BC005267 AAH05267 BC136294 AAI36295 BC150310 BU681199 CD615451 Y13247 CAA73697 XM_006715130 XP_006715193 XM_006725489 XP_006725552 XM_006725703 XP_006725766 XM_006725820 XP_006725883 XM_006725912 XP_006725975 XM_006726005 XP_006726068 XM_006726100 XP_006726163 XM_011514722 XP_011513024 XM_011547261 XP_011545563 XM_011547664 XP_011545966 XM_011547896 XP_011546198 XM_011548062 XP_011546364 XM_011548252 XP_011546554 XM_011548452 XP_011546754 NM_002714 NP_002705 NR_072994
Function Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00649, ECO:0000269|PubMed:9450550}. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9450550, ECO:0000269|PubMed:9784381}.

PNUTS Antibody - 14171 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MCF7, HT-29 and HeLa cells using PNUTS Antibody.

PNUTS (F-8) - sc-271681 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PNUTS (F-8): sc-271681. Western blot analysis of PNUTS expression in SK-N-MC (A) and H4 (B) whole cell lysates.

PNUTS (H-94) - sc-135164 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PNUTS (H-94): sc-135164. Western blot analysis of PNUTS expression in mouse brain tissue extract.

PNUTS (N-18) - sc-47340 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PNUTS (N-18): sc-47340. Western blot analysis of PNUTS expression in SK-N-MC nuclear extract.

PNUTS (N-13) - sc-47339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PNUTS (N-13): sc-47339. Western blot analysis of PNUTS expression in mouse brain tissue extract.

PNUTS (47) - sc-136044 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PNUTS (47): sc-136044. Western blot analysis of PNUTS expression in rat brain tissue extract.

Anti-PPP1R10 antibody - ab70247 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling PPP1R10 with ab70247 at 1/1000 (1µg/ml). Detection: DAB.

Anti-PPP1R10 antibody - ab52780 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-PPP1R10 antibody (ab52780) at 1/1000 dilutionLane 1 : a total protein extract from E coli with 50ng to 100 ng of a tagged fusion protein of an irrelevant antigen. Lane 2 : a total protein extract from E coli with 50ng to 500ng of the antigen (tagged-antigen fusion protein)Lysates/proteins at 20 µg per lane.SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilution

Anti-PPP1R10 antibody - ab74589 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PPP1R10 antibody (ab74589) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Nuclear Lysate Lane 2 : HepG2 (Human epithelial carcinoma cell line) Nuclear Lysate Lane 3 : Jurkat (Human T cell lymphoblast-like cell line) Nuclear Lysate (ab14844)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-PPP1R10 antibody - ab70248 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lanes 1 - 2 : Anti-PPP1R10 antibody (ab70248) at 1 µg/mlLanes 3 - 4 : Anti-PPP1R10 antibody (ab70248) at 0.2 µg/mlLane 1 : Nuclear extracts from Hela cells at 15 µgLane 2 : Nuclear extracts from Hela cells at 45 µgLane 3 : Nuclear extracts from Hela cells at 15 µgLane 4 : Nuclear extracts from Hela cells at 45 µg

Anti-PPP1R10 antibody - ab134291 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PPP1R10 antibody (ab134291) at 1/500 dilution + HepG2 cell lysate

Anti-PPP1R10 antibody - ab66040 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PPP1R10 antibody (ab66040) at 1 µg/ml + HeLa (Human epithelial carcinoma cell line) Nuclear Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-PPP1R10 antibody - ab84377 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84377 at 1/250, staining human PPP1R10 in a section of human breast adenocarcinoma by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-PPP1R10 antibody [EPR11706] - ab173285 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11706
All lanes : Anti-PPP1R10 antibody [EPR11706] (ab173285) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Human fetal brain lysateLane 3 : HepG2 cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-PPP1R10 / PNUTS Antibody (aa350-400) IHC-plus™ - LS-B11298 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PPP1R10 / PNUTS antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11298 concentration 5 ug/ml.

Anti-PPP1R10 / PNUTS Antibody (aa350-400) - LS-C91563 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R10 / PNUTS Antibody (C-Terminus) - LS-C91564 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R10 / PNUTS Antibody (aa1-50) - LS-C91562 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R10 / PNUTS Antibody (C-Terminus) - LS-C287329 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R10 / PNUTS Antibody (aa146-195) - LS-C80326 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-PPP1R10 / PNUTS Antibody (aa350-400) - LS-C286325 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PNUTS by Immunohistochemistry. Sample: FFPE section of human breast adenocarcinoma. Antibody: Affinity purified rabbit anti-PNUTS used at a dilution of 1:250. Detection: DAB.

Anti-PPP1R10 / PNUTS Antibody (clone 1D6) - LS-C197969 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D6
Western Blot analysis of PPP1R10 expression in transfected 293T cell line by PPP1R10 monoclonal antibody (M02), clone 1D6.Lane 1: PPP1R10 transfected lysate(99.1 KDa).Lane 2: Non-transfected lysate.

Anti-PPP1R10 / PNUTS Antibody (aa1-50) - LS-C286000 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PNUTS by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-PNUTS used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-PPP1R10 / PNUTS Antibody - LS-C334485 from LifeSpan Bioscience

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using PPP1R10 antibody.

Anti-PPP1R10 / PNUTS Antibody IHC-plus™ - LS-B7130 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PPP1R10 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7130 concentration 5 ug/ml.
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