Gene Symbol | PIGK |
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Entrez Gene | 10026 |
Alt Symbol | GPI8 |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidylinositol glycan anchor biosynthesis, class K |
Other Description | GPI transamidase subunit|GPI-anchor transamidase|GPI8 homolog|PIG-K|phosphatidylinositol glycan, class K|phosphatidylinositol-glycan biosynthesis class K protein |
Swissprots | B4E2M3 B2R7K3 Q5TG77 O14822 Q92643 |
Accessions | EAX06380 EAX06381 EAX06382 EAX06383 Q92643 AF022913 AAB81597 AK055071 AK304340 BAG65185 AK313015 BAG35850 BC020737 AAH20737 BC026186 BX648473 DA263434 HQ447704 ADQ32189 Y07596 CAA68871 NM_005482 NP_005473 |
Function | Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Single-pass type I membrane protein {ECO:0000269|PubMed:11483512}. |
Top Pathways | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
PIG-K CRISPR/Cas9 KO Plasmid (h) - sc-411406 from Santa Cruz Biotechnology
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PIG-K HDR Plasmid (h) - sc-411406-HDR from Santa Cruz Biotechnology
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PIG-K Double Nickase Plasmid (h) - sc-411406-NIC from Santa Cruz Biotechnology
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PIG-K Double Nickase Plasmid (h2) - sc-411406-NIC-2 from Santa Cruz Biotechnology
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PIG-K CRISPR Activation Plasmid (h) - sc-411406-ACT from Santa Cruz Biotechnology
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PIG-K CRISPR Activation Plasmid (h2) - sc-411406-ACT-2 from Santa Cruz Biotechnology
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PIG-K Lentiviral Activation Particles (h) - sc-411406-LAC from Santa Cruz Biotechnology
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PIG-K Lentiviral Activation Particles (h2) - sc-411406-LAC-2 from Santa Cruz Biotechnology
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PIG-K siRNA (h) - sc-62804 from Santa Cruz Biotechnology
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PIG-K shRNA Plasmid (h) - sc-62804-SH from Santa Cruz Biotechnology
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PIG-K shRNA (h) Lentiviral Particles - sc-62804-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU067551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16788 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16788 from Sigma-Aldrich
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PIGK siRNA (Human) - CRH6753 from Cohesion Biosciences
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GPI8 RNAi - H00010026-R01 from Novus Biologicals
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shRNA set against Human PIGK (NM_005482.2) - SHH375420 from Creative biogene
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shRNA set against Human PIGK(NM_005482.2) - SHR114016 from Creative biogene
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Human PIGK siRNA - orb267255 from Biorbyt
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PIGK shRNA Plasmid (Human) - CHH6753 from Cohesion Biosciences
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PIGK miRNA 3'UTR clone - MiUTR1H-07892 from Creative biogene
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