| Gene Symbol |
PIGK
|
| Entrez Gene |
10026
|
| Alt Symbol |
GPI8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol glycan anchor biosynthesis, class K
|
| Other Description |
GPI transamidase subunit|GPI-anchor transamidase|GPI8 homolog|PIG-K|phosphatidylinositol glycan, class K|phosphatidylinositol-glycan biosynthesis class K protein
|
| Swissprots |
B4E2M3 B2R7K3 Q5TG77 O14822 Q92643
|
| Accessions |
EAX06380 EAX06381 EAX06382 EAX06383 Q92643 AF022913 AAB81597 AK055071 AK304340 BAG65185 AK313015 BAG35850 BC020737 AAH20737 BC026186 BX648473 DA263434 HQ447704 ADQ32189 Y07596 CAA68871 NM_005482 NP_005473
|
| Function |
Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Single-pass type I membrane protein {ECO:0000269|PubMed:11483512}.
|
| Top Pathways |
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
|
![Western Blot: GPI8 Overexpression Lysate (Adult Normal) [NBL1-14399] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GPI8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2690_GPI8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14399-img0002.jpg)