| Gene Symbol | PIGK |
|---|---|
| Entrez Gene | 10026 |
| Alt Symbol | GPI8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidylinositol glycan anchor biosynthesis, class K |
| Other Description | GPI transamidase subunit|GPI-anchor transamidase|GPI8 homolog|PIG-K|phosphatidylinositol glycan, class K|phosphatidylinositol-glycan biosynthesis class K protein |
| Swissprots | B4E2M3 B2R7K3 Q5TG77 O14822 Q92643 |
| Accessions | EAX06380 EAX06381 EAX06382 EAX06383 Q92643 AF022913 AAB81597 AK055071 AK304340 BAG65185 AK313015 BAG35850 BC020737 AAH20737 BC026186 BX648473 DA263434 HQ447704 ADQ32189 Y07596 CAA68871 NM_005482 NP_005473 |
| Function | Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Single-pass type I membrane protein {ECO:0000269|PubMed:11483512}. |
| Top Pathways | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |