UBE2D2
| Gene Symbol | UBE2D2 |
|---|---|
| Entrez Gene | 7322 |
| Alt Symbol | E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B |
| Species | Human |
| Gene Type | protein-coding |
| Description | ubiquitin-conjugating enzyme E2D 2 |
| Other Description | p53-regulated ubiquitin-conjugating enzyme 1|ubiquitin carrier protein D2|ubiquitin-conjugating enzyme E2 D2|ubiquitin-conjugating enzyme E2-17 kDa 2|ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)|ubiquitin-protein ligase D2 |
| Swissprots | Q96RP6 Q3MN78 D3DQC9 P62837 |
| Accessions | AAC41750 EAW62095 EAW62096 EAW62097 P62837 AF317220 AAK93958 AK001311 BAG50891 AK001428 BAG50911 AK310273 AY651263 AAX35690 BC019052 BC033349 AAH33349 BC048426 BQ186099 U39317 AAA91460 XM_011537679 XP_011535981 NM_003339 NP_003330 NM_181838 NP_862821 |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20403326, ECO:0000269|PubMed:20525694}. |
| Top Pathways | Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum |
UBE2D2 CRISPR/Cas9 KO Plasmid (h) - sc-418322 from Santa Cruz Biotechnology
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UBE2D2 HDR Plasmid (h) - sc-418322-HDR from Santa Cruz Biotechnology
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UBE2D2 Double Nickase Plasmid (h) - sc-418322-NIC from Santa Cruz Biotechnology
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UBE2D2 Double Nickase Plasmid (h2) - sc-418322-NIC-2 from Santa Cruz Biotechnology
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UBE2D2 CRISPR Activation Plasmid (h) - sc-418322-ACT from Santa Cruz Biotechnology
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UBE2D2 CRISPR Activation Plasmid (h2) - sc-418322-ACT-2 from Santa Cruz Biotechnology
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UBE2D2 Lentiviral Activation Particles (h) - sc-418322-LAC from Santa Cruz Biotechnology
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UBE2D2 Lentiviral Activation Particles (h2) - sc-418322-LAC-2 from Santa Cruz Biotechnology
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UBE2D2 siRNA (h) - sc-36771 from Santa Cruz Biotechnology
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UBE2D2 shRNA Plasmid (h) - sc-36771-SH from Santa Cruz Biotechnology
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UBE2D2 shRNA (h) Lentiviral Particles - sc-36771-V from Santa Cruz Biotechnology
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UbcH5b/UBE2D2 RNAi - H00007322-R01 from Novus Biologicals
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UbcH5b/UBE2D2 RNAi - H00007322-R02 from Novus Biologicals
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MISSION® esiRNA - EHU063521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22357 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22357 from Sigma-Aldrich
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UBE2D2 siRNA (Human) - CRH5005 from Cohesion Biosciences
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UBE2D2 - MBS8226154 from MyBioSource
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shRNA set against Human UBE2D2 (NM_181838.1) - SHH438892 from Creative biogene
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shRNA set against Human UBE2D2(NM_003339.2) - SHL110620 from Creative biogene
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shRNA set against Human UBE2D2(NM_181838.1) - SHL110700 from Creative biogene
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Human UBE2D2 siRNA - orb265507 from Biorbyt
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UBE2D2 shRNA Plasmid (Human) - CHH5005 from Cohesion Biosciences
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UBE2D2 miRNA 3'UTR clone - MiUTR1H-10941 from Creative biogene
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UBE2D2 miRNA 3'UTR clone - MiUTR1H-10942 from Creative biogene
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