UBE2D2

Gene Symbol	UBE2D2
Entrez Gene	7322
Alt Symbol	E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2D 2
Other Description	p53-regulated ubiquitin-conjugating enzyme 1|ubiquitin carrier protein D2|ubiquitin-conjugating enzyme E2 D2|ubiquitin-conjugating enzyme E2-17 kDa 2|ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)|ubiquitin-protein ligase D2
Swissprots	Q96RP6 Q3MN78 D3DQC9 P62837
Accessions	AAC41750 EAW62095 EAW62096 EAW62097 P62837 AF317220 AAK93958 AK001311 BAG50891 AK001428 BAG50911 AK310273 AY651263 AAX35690 BC019052 BC033349 AAH33349 BC048426 BQ186099 U39317 AAA91460 XM_011537679 XP_011535981 NM_003339 NP_003330 NM_181838 NP_862821
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20403326, ECO:0000269|PubMed:20525694}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBE2D2 full length protein - ab109971 from Abcam Category Protein Source E. coli Species Human

Human UBE2D2 full length protein - ab111451 from Abcam Category Protein Source E. coli Species Human

Human UBE2D2 full length protein (Tagged) - Chemical Free - ab81575 from Abcam Category Protein Source E. coli Species Human

UBE2D2 protein (His tag) - ab127403 from Abcam Category Protein Source E. coli Species Human

UBE2D2 / UBCH5B Antibody Blocking Peptide - LS-E3555 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2D2 / UBCH5B Antibody Blocking Peptide - LS-E15826 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2D2 / UBCH5B Antibody Blocking Peptide - LS-E15828 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UbcH5b/UBE2D2 Recombinant Protein - H00007322-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UbcH5b/UBE2D2 Partial Recombinant Protein - H00007322-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human UbcH5b/UBE2D2 Protein - NBP1-99190 from Novus Biologicals Category Protein Prices $145.00 Sizes 10 µg Source E. coli Species Human

UbcH5b/UBE2D2 Protein - NBP1-99628 from Novus Biologicals Category Protein Species Human

Recombinant Human UbcH5b/UBE2D2 Protein - NBP1-72392 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

UBE2D2-Antibody-C-term-Blocking-Peptide - BP14752b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2D2 Protein - GTX117600-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Recombinant Human UbcH5b/UBE2D2, CF - E2-622-050 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human UbcH5b/UBE2D2, CF - E2-622-100 from R&D Systems Category Protein Source E. coli-derived,

Human UBE2D2 protein - orb169504 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

UBCH5b protein (His tag) - 80R-2540 from Fitzgerald Category Protein Prices $195.00 Sizes 10 µg Source E.coli Species Human

UBE2D2 Blocking Peptide - 33R-8733 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBE2D2 Blocking Peptide - 33R-9123 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBE2D2 Blocking Peptide - 33R-1345 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBE2D2 Blocking Peptide - abx063398 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig

UBE2D2 (1-147, His-tag) - AR39087PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

UBE2D2 (1-147, His-tag) - AR39087PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

UBE2D2 - H00007322-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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