UBE2D2

Gene Symbol	UBE2D2
Entrez Gene	7322
Alt Symbol	E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2D 2
Other Description	p53-regulated ubiquitin-conjugating enzyme 1|ubiquitin carrier protein D2|ubiquitin-conjugating enzyme E2 D2|ubiquitin-conjugating enzyme E2-17 kDa 2|ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)|ubiquitin-protein ligase D2
Swissprots	Q96RP6 Q3MN78 D3DQC9 P62837
Accessions	AAC41750 EAW62095 EAW62096 EAW62097 P62837 AF317220 AAK93958 AK001311 BAG50891 AK001428 BAG50911 AK310273 AY651263 AAX35690 BC019052 BC033349 AAH33349 BC048426 BQ186099 U39317 AAA91460 XM_011537679 XP_011535981 NM_003339 NP_003330 NM_181838 NP_862821
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20403326, ECO:0000269|PubMed:20525694}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UBE2D2 overexpression lysate - LY405611 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

UBE2D2 overexpression lysate - LY418757 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

UBE2D2 293 Cell Lysate - 408763 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

UBE2D2 293 Cell Lysate - 403659 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

UbcH5b/UBE2D2 Overexpression Lysate (Native) - NBL1-17520 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

UbcH5b/UBE2D2 Overexpression Lysate (Native) - NBL1-17519 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

UBE2D2 Over-expression Lysate Product - GWB-DE7952 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

UBE2D2 Over-expression Lysate Product - GWB-9D3D58 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

UBE2D2 knockout Cell lysate - LC810838 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human UBE2D2 Knockdown Stable Cell Line - CSC-DC016951 from Creative biogene Category Cell Line Species Human

Human UBE2D2 Knockout Cell Line-HeLa - CSC-RT0841 from Creative biogene Category Cell Line Species Human

UBE2D2 KO Cell Lysate-HeLa - CLKO-0344 from Creative biogene Category Cell Lysate

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