| Gene Symbol |
UBE2D2
|
| Entrez Gene |
7322
|
| Alt Symbol |
E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2D 2
|
| Other Description |
p53-regulated ubiquitin-conjugating enzyme 1|ubiquitin carrier protein D2|ubiquitin-conjugating enzyme E2 D2|ubiquitin-conjugating enzyme E2-17 kDa 2|ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)|ubiquitin-protein ligase D2
|
| Swissprots |
Q96RP6 Q3MN78 D3DQC9 P62837
|
| Accessions |
AAC41750 EAW62095 EAW62096 EAW62097 P62837 AF317220 AAK93958 AK001311 BAG50891 AK001428 BAG50911 AK310273 AY651263 AAX35690 BC019052 BC033349 AAH33349 BC048426 BQ186099 U39317 AAA91460 XM_011537679 XP_011535981 NM_003339 NP_003330 NM_181838 NP_862821
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:18703417, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20403326, ECO:0000269|PubMed:20525694}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum
|