FAIM3

Gene Symbol FAIM3
Entrez Gene 9214
Alt Symbol FCMR, TOSO
Species Human
Gene Type protein-coding
Description Fas apoptotic inhibitory molecule 3
Other Description Fc mu receptor|IgM Fc receptor|fas apoptotic inhibitory molecule 3|immunoglobulin mu Fc receptor|regulator of Fas-induced apoptosis Toso
Swissprots O60667 B7Z6Z0 D9MWM3 A8K7J2
Accessions CBX53827 EAW93517 O60667 AA769146 AF057557 AAC18830 AI524407 AK292007 BAF84696 AK297053 BAH12483 AK301187 BAH13426 AK316336 BAH14707 BC006401 AAH06401 BP225124 BP305798 BP338035 BT006797 AAP35443 CB158779 DA971987 DB122623 DC393681 DQ890699 ABM81625 GQ160900 ACX94154 GQ160901 ACX94155 HM480394 ADK11426 XM_005273351 XP_005273408 XM_005273352 XP_005273409 XR_921999 NM_001142472 NM_001142473 NP_001135945 NM_001193338 NP_001180267 NM_005449 NP_005440
Function May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. {ECO:0000269|PubMed:9586636}.
Subcellular Location Isoform 1: Membrane; Single-pass membrane protein.
Tissue Specificity Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells. {ECO:0000269|PubMed:21908424, ECO:0000269|PubMed:9586636}.

Toso CRISPR/Cas9 KO Plasmid (h) - sc-405712 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Toso HDR Plasmid (h) - sc-405712-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Toso Double Nickase Plasmid (h) - sc-405712-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Toso Double Nickase Plasmid (h2) - sc-405712-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Toso CRISPR Activation Plasmid (h) - sc-405712-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Toso CRISPR Activation Plasmid (h2) - sc-405712-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Toso Lentiviral Activation Particles (h) - sc-405712-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Toso Lentiviral Activation Particles (h2) - sc-405712-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Toso siRNA (h) - sc-106628 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Toso shRNA Plasmid (h) - sc-106628-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Toso shRNA (h) Lentiviral Particles - sc-106628-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU052131 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8102 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8102 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05450 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05450

FAIM3 siRNA (Human) - CRH6099 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FAIM3 RNAi - H00009214-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FAIM3 - MBS8227324 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FAIM3 (NM_005449.4) - SHH288845 from Creative biogene

Category siRNA
Species Reactivities Human

FAIM3 shRNA Plasmid (Human) - CHH6099 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FAIM3 miRNA 3'UTR clone - MiUTR3H-08135 from Creative biogene

Species Reactivities Human

FAIM3 miRNA 3'UTR clone - MiUTR3H-08136 from Creative biogene

Species Reactivities Human
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