| Gene Symbol | FAIM3 |
|---|---|
| Entrez Gene | 9214 |
| Alt Symbol | FCMR, TOSO |
| Species | Human |
| Gene Type | protein-coding |
| Description | Fas apoptotic inhibitory molecule 3 |
| Other Description | Fc mu receptor|IgM Fc receptor|fas apoptotic inhibitory molecule 3|immunoglobulin mu Fc receptor|regulator of Fas-induced apoptosis Toso |
| Swissprots | O60667 B7Z6Z0 D9MWM3 A8K7J2 |
| Accessions | CBX53827 EAW93517 O60667 AA769146 AF057557 AAC18830 AI524407 AK292007 BAF84696 AK297053 BAH12483 AK301187 BAH13426 AK316336 BAH14707 BC006401 AAH06401 BP225124 BP305798 BP338035 BT006797 AAP35443 CB158779 DA971987 DB122623 DC393681 DQ890699 ABM81625 GQ160900 ACX94154 GQ160901 ACX94155 HM480394 ADK11426 XM_005273351 XP_005273408 XM_005273352 XP_005273409 XR_921999 NM_001142472 NM_001142473 NP_001135945 NM_001193338 NP_001180267 NM_005449 NP_005440 |
| Function | May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. {ECO:0000269|PubMed:9586636}. |
| Subcellular Location | Isoform 1: Membrane; Single-pass membrane protein. |
| Tissue Specificity | Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells. {ECO:0000269|PubMed:21908424, ECO:0000269|PubMed:9586636}. |