| Gene Symbol | RAD9A |
|---|---|
| Entrez Gene | 5883 |
| Alt Symbol | RAD9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAD9 homolog A (S. pombe) |
| Other Description | DNA repair exonuclease rad9 homolog A|cell cycle checkpoint control protein RAD9A|hRAD9 |
| Swissprots | B2RCZ8 Q96C41 Q6FI29 Q99638 |
| Accessions | AAU89725 BAH69085 BAH69086 BAH69087 EAW74604 EAW74605 EAW74606 Q99638 AA708970 AK310213 AK315348 BAG37745 BC014848 AAH14848 CB164642 CN402466 CR536508 CAG38746 U53174 AAB39928 XM_006718652 XP_006718715 XM_011545205 XP_011543507 XR_428922 NM_001243224 NP_001230153 NM_004584 NP_004575 |
| Function | Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12628935}. |
Rad9 CRISPR/Cas9 KO Plasmid (h) - sc-401995 from Santa Cruz Biotechnology
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Rad9 HDR Plasmid (h) - sc-401995-HDR from Santa Cruz Biotechnology
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Rad9 Double Nickase Plasmid (h) - sc-401995-NIC from Santa Cruz Biotechnology
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Rad9 Double Nickase Plasmid (h2) - sc-401995-NIC-2 from Santa Cruz Biotechnology
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Rad9 CRISPR Activation Plasmid (h) - sc-401995-ACT from Santa Cruz Biotechnology
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Rad9 CRISPR Activation Plasmid (h2) - sc-401995-ACT-2 from Santa Cruz Biotechnology
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Rad9 Lentiviral Activation Particles (h) - sc-401995-LAC from Santa Cruz Biotechnology
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Rad9 Lentiviral Activation Particles (h2) - sc-401995-LAC-2 from Santa Cruz Biotechnology
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Rad9 siRNA (h) - sc-36364 from Santa Cruz Biotechnology
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Rad9 shRNA Plasmid (h) - sc-36364-SH from Santa Cruz Biotechnology
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Rad9 shRNA (h) Lentiviral Particles - sc-36364-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU057901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1436 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17907 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1437 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1438 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1436 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1437 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17907 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1438 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06675 from Sigma-Aldrich
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RAD9A siRNA (Human) - CRH3972 from Cohesion Biosciences
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RAD9A - MBS8230678 from MyBioSource
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RAD9A - MBS826825 from MyBioSource
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shRNA set against Human RAD9A(NM_004584.2) - SHR162318 from Creative biogene
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