| Gene Symbol |
RAD9A
|
| Entrez Gene |
5883
|
| Alt Symbol |
RAD9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAD9 homolog A (S. pombe)
|
| Other Description |
DNA repair exonuclease rad9 homolog A|cell cycle checkpoint control protein RAD9A|hRAD9
|
| Swissprots |
B2RCZ8 Q96C41 Q6FI29 Q99638
|
| Accessions |
AAU89725 BAH69085 BAH69086 BAH69087 EAW74604 EAW74605 EAW74606 Q99638 AA708970 AK310213 AK315348 BAG37745 BC014848 AAH14848 CB164642 CN402466 CR536508 CAG38746 U53174 AAB39928 XM_006718652 XP_006718715 XM_011545205 XP_011543507 XR_428922 NM_001243224 NP_001230153 NM_004584 NP_004575
|
| Function |
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12628935}.
|