CXADR

Gene Symbol CXADR
Entrez Gene 1525
Alt Symbol CAR, CAR4/6, HCAR
Species Human
Gene Type protein-coding
Description coxsackie virus and adenovirus receptor
Other Description 46 kD coxsackievirus and adenovirus receptor (CAR) protein|CVB3-binding protein|HCVADR|coxsackievirus B-adenovirus receptor|coxsackievirus and adenovirus receptor
Swissprots D3YHP0 B7WPI3 Q8WWT8 P78310 B2R8V8 O00694 Q8WWT6 Q8WWT7 Q9UKV4
Accessions AAF05908 AAF24344 AAG01088 EAX10030 EAX10031 EAX10032 EAX10033 P78310 AF124598 AAD31772 AI498294 AK313526 BAG36305 AY072910 AAL68878 AY072911 AAL68879 AY072912 AAL68880 BC003684 AAH03684 BC010536 AAH10536 BM547121 BT019876 AAV38679 CV570985 DQ891181 ABM82107 DQ894363 ABM85289 GU474812 ADC84500 U90716 AAC51234 Y07593 CAA68868 XM_011529475 XP_011527777 XM_011529476 XP_011527778 XM_011529477 XP_011527779 XM_011529478 XP_011527780 XM_011529479 XP_011527781 NM_001207063 NP_001193992 NM_001207064 NP_001193993 NM_001207065 NP_001193994 NM_001207066 NP_001193995 NM_001338 NP_001329
Function Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.
Subcellular Location Isoform 5: Secreted.
Tissue Specificity Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. {ECO:0000269|PubMed:10490761, ECO:0000269|PubMed:11457744, ECO:0000269|PubMed:11549277, ECO:0000269|PubMed:9096397}.

CAR CRISPR/Cas9 KO Plasmid (h) - sc-418548 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CAR HDR Plasmid (h) - sc-418548-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CAR Double Nickase Plasmid (h) - sc-418548-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CAR Double Nickase Plasmid (h2) - sc-418548-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CAR CRISPR Activation Plasmid (h) - sc-418548-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CAR CRISPR Activation Plasmid (h2) - sc-418548-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CAR Lentiviral Activation Particles (h) - sc-418548-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CAR Lentiviral Activation Particles (h2) - sc-418548-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CAR siRNA (h) - sc-29906 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CAR shRNA Plasmid (h) - sc-29906-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CAR shRNA (h) Lentiviral Particles - sc-29906-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CXADR RNAi - H00001525-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU096301 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6793 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6793 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09130 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09130

CXADR siRNA (Human) - CRH1080 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CXADR - MBS8241151 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human CXADR siRNA - orb261582 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CXADR shRNA Plasmid (Human) - CHH1080 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CXADR miRNA 3'UTR clone - MiUTR3H-05140 from Creative biogene

Species Reactivities Human
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