CXADR

Gene Symbol	CXADR
Entrez Gene	1525
Alt Symbol	CAR, CAR4/6, HCAR
Species	Human
Gene Type	protein-coding
Description	coxsackie virus and adenovirus receptor
Other Description	46 kD coxsackievirus and adenovirus receptor (CAR) protein|CVB3-binding protein|HCVADR|coxsackievirus B-adenovirus receptor|coxsackievirus and adenovirus receptor
Swissprots	D3YHP0 B7WPI3 Q8WWT8 P78310 B2R8V8 O00694 Q8WWT6 Q8WWT7 Q9UKV4
Accessions	AAF05908 AAF24344 AAG01088 EAX10030 EAX10031 EAX10032 EAX10033 P78310 AF124598 AAD31772 AI498294 AK313526 BAG36305 AY072910 AAL68878 AY072911 AAL68879 AY072912 AAL68880 BC003684 AAH03684 BC010536 AAH10536 BM547121 BT019876 AAV38679 CV570985 DQ891181 ABM82107 DQ894363 ABM85289 GU474812 ADC84500 U90716 AAC51234 Y07593 CAA68868 XM_011529475 XP_011527777 XM_011529476 XP_011527778 XM_011529477 XP_011527779 XM_011529478 XP_011527780 XM_011529479 XP_011527781 NM_001207063 NP_001193992 NM_001207064 NP_001193993 NM_001207065 NP_001193994 NM_001207066 NP_001193995 NM_001338 NP_001329
Function	Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.
Subcellular Location	Isoform 5: Secreted.
Tissue Specificity	Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. {ECO:0000269|PubMed:10490761, ECO:0000269|PubMed:11457744, ECO:0000269|PubMed:11549277, ECO:0000269|PubMed:9096397}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Coxsackie Adenovirus Receptor protein fragment - ab168893 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Human

Human Coxsackie Adenovirus Receptor full length protein - ab114429 from Abcam Category Protein Source Wheat germ Species Human

Human Coxsackie Adenovirus Receptor full length protein - ab152313 from Abcam Category Protein Source Wheat germ Species Human

Human Coxsackie Adenovirus Receptor protein fragment - ab168070 from Abcam Category Protein Source E. coli Species Human

Human Coxsackie Adenovirus Receptor protein fragment - ab151334 from Abcam Category Protein Source HEK 293 cells Species Human

CXADR Antibody Blocking Peptide - LS-E29501 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CXADR Antibody Blocking Peptide - LS-E29500 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CXADR Antibody Blocking Peptide - LS-E11655 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CXADR Antibody Blocking Peptide - LS-E7150 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CXADR Recombinant Protein - H00001525-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Recombinant Human CXADR Protein - NBP2-22802 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

CXADR-Antibody-Center-Blocking-Peptide - BP2852c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human CXADR Fc Chimera, CF - 3336-CX-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human CXADR protein - orb191182 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human CXADR protein - orb49311 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

Human CXADR His tag protein - orb84437 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human CXADR Fc His tag protein - orb82931 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

CXADR Blocking Peptide - 33R-4065 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CXADR Blocking Peptide - abx062498 from Abbexa Category Peptide Species Human, Mouse, Rat

CXADR (20-237, His-tag) - AR51025PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CXADR (20-237, His-tag) - AR51025PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CXADR - H00001525-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

CXADR - H00001525-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

CXADR - H00001525-P02-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

CXADR - H00001525-P02-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

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