CXADR

Gene Symbol CXADR
Entrez Gene 1525
Alt Symbol CAR, CAR4/6, HCAR
Species Human
Gene Type protein-coding
Description coxsackie virus and adenovirus receptor
Other Description 46 kD coxsackievirus and adenovirus receptor (CAR) protein|CVB3-binding protein|HCVADR|coxsackievirus B-adenovirus receptor|coxsackievirus and adenovirus receptor
Swissprots D3YHP0 B7WPI3 Q8WWT8 P78310 B2R8V8 O00694 Q8WWT6 Q8WWT7 Q9UKV4
Accessions AAF05908 AAF24344 AAG01088 EAX10030 EAX10031 EAX10032 EAX10033 P78310 AF124598 AAD31772 AI498294 AK313526 BAG36305 AY072910 AAL68878 AY072911 AAL68879 AY072912 AAL68880 BC003684 AAH03684 BC010536 AAH10536 BM547121 BT019876 AAV38679 CV570985 DQ891181 ABM82107 DQ894363 ABM85289 GU474812 ADC84500 U90716 AAC51234 Y07593 CAA68868 XM_011529475 XP_011527777 XM_011529476 XP_011527778 XM_011529477 XP_011527779 XM_011529478 XP_011527780 XM_011529479 XP_011527781 NM_001207063 NP_001193992 NM_001207064 NP_001193993 NM_001207065 NP_001193994 NM_001207066 NP_001193995 NM_001338 NP_001329
Function Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.
Subcellular Location Isoform 5: Secreted.
Tissue Specificity Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. {ECO:0000269|PubMed:10490761, ECO:0000269|PubMed:11457744, ECO:0000269|PubMed:11549277, ECO:0000269|PubMed:9096397}.

CAR Antibody - 13947 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using CAR Antibody.

CAR (K-20) - sc-10314 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CAR (K-20): sc-10314. Western blot analysis of CAR expression in non-transfected: sc-110760 (A) and human CAR transfected: sc-112300 (B) 293 whole cell lysates.

CAR (A-10) - sc-365836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CAR (A-10): sc-365836. Western blot analysis of CAR expression in non-transfected: sc-117752 (A) and human CAR transfected: sc-159755 (B) 293T whole cell lysates.

CAR (E1-1) - sc-56892 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CAR (E1-1): sc-56892. Western blot analysis of CAR expression in non-transfected: sc-110760 (A) and human CAR transfected: sc-112300 (B) 293 whole cell lysates.

CAR (E-1) - sc-373791 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CAR (E-1): sc-373791. Western blot analysis of CAR expression in non-transfected: sc-117752 (A) and human CAR transfected: sc-159755 (B) whole cell lysates.

CAR (H-300) - sc-15405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CAR (H-300): sc-15405. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate cancer showing membrane and cytoplasmic staining of tumor cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

CAR (Mab.E(mh) 1) - sc-32795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CAR (Mab.E(mh) 1): sc-32795. Western blot analysis of CAR expression in A549 whole cell lysate.

CAR (N-17) - sc-10313 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CAR (N-17): sc-10313. Western blot analysis of CAR expression in non-transfected: sc-110760 (A) and human CAR transfected: sc-112300 (B) 293 whole cell lysates.

CAR (3C100) - sc-70493 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CAR (3C100): sc-70493. Western blot analysis of CAR expression in non-transfected: sc-110760 (A) and human CAR transfected: sc-112300 (B) 293 whole cell lysates.

Anti-Coxsackie Adenovirus Receptor antibody - ab167062 from Abcam

Prices $376.00
Sizes 500 µg
Host Chicken
Clonality Polyclonal
Anti-Coxsackie Adenovirus Receptor antibody (ab167062) at 1/500 dilution + Recombinant Coxsackie Adenovirus Receptor protein

Anti-Coxsackie Adenovirus Receptor antibody - ab133380 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Coxsackie Adenovirus Receptor expression in Formalin-Fixed, Paraffin-Embedded Human testis tissue using 10 µg/ml ab133380.

Anti-Coxsackie Adenovirus Receptor antibody [2T6] - ab62497 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2T6

Anti-Coxsackie Adenovirus Receptor antibody - N-terminal - ab189216 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human small intestine tissue labeling Coxsackie Adenovirus Receptor with ab189216 at 20 µg/ml.

Anti-CXADR Antibody (Internal) - LS-C97350 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of anti-CXADR Antibody in NCI-H460 cell line lysates (35 ug/lane). CXADR(arrow) was detected using the purified antibody.

Anti-CXADR Antibody (Internal) IHC-plus™ - LS-A8846 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CXADR antibody LS-A8846 IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CXADR Antibody (Internal) IHC-plus™ - LS-A8845 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CXADR antibody LS-A8845 IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CXADR Antibody - LS-C21204 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CXADR Antibody (aa72-121) - LS-C80042 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-CXADR Antibody (aa38-87) - LS-C291839 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CXADR Antibody - LS-C310038 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CXADR Antibody (aa48-93) - LS-C313692 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CXADR Antibody (aa313-328) - LS-C313489 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
WB of CXADR antibody. Lane 1: Rat Pancreas Tissue Lysate. Lane 2: Rat Brain Tissue Lysate. Lane 3: Rat Heart Tissue Lysate. Lane 4: HELA Cell Lysate. Lane 5: 293T Cell Lysate. Lane 6: COLO320 Cell Lysate.

Anti-CXADR Antibody - LS-C341144 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CXADR Antibody IHC-plus™ - LS-B8019 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Anti-CXADR antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8019 dilution 5 ug/ml.

Anti-CXADR Antibody (aa1-50) IHC-plus™ - LS-B8702 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CXADR antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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