PROX1

Gene Symbol PROX1
Entrez Gene 5629
Alt Symbol -
Species Human
Gene Type protein-coding
Description prospero homeobox 1
Other Description homeobox prospero-like protein PROX1|prospero homeobox protein 1|prospero-related homeobox 1
Swissprots Q8TB91 A6NK29 Q92786 Q5SW76 A8K2B1
Accessions EAW93359 EAW93360 Q92786 AK025453 AK298182 BAG60453 BC024201 AAH24201 DA743374 DA802102 DB086260 EU446861 ABZ92390 U44060 AAC50656 XM_005273194 XP_005273251 XM_005273195 XP_005273252 XM_011509771 XP_011508073 XM_011509772 XP_011508074 XM_011509773 XP_011508075 XM_011509774 XP_011508076 NM_001270616 NP_001257545 NM_002763 NP_002754
Function Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}.
Subcellular Location Nucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization. {ECO:0000250|UniProtKB:P48437}.
Tissue Specificity Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:8812486}.

PROX1 Antibody - 13910 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Huh7, Hep G2, and SW620 cells using PROX1 Antibody.

PROX1 (C-12)-R - sc-22135-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal

PROX1 (A-19)-R - sc-22134-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal

PROX1 (H-160) - sc-292955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PROX1 (H-160): sc-292955. Western blot analysis of PROX1 expression in A2058 (A), A431 (B) and MCF7 (C) whole cell lysates and HeLa nuclear extract (D).

PROX1 (FM-79) - sc-81983 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PROX1 (FM-79): sc-81983. Western blot analysis of PROX1 expression in human skeletal muscle tissue extract.

Anti-PROX1 antibody - ab38692 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PROX1 antibody (ab38692) at 1 µg/ml (3% Milk Block)Lane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate (ab52257)Lane 2 : SHSY-5Y (Human neuroblastoma cell line) Whole Cell Lysate (ab45968)Lane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate (ab52256)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PROX1 antibody - ab101851 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Frozen sections) analysis of mouse embryo (day 13.5) tissue sections labelling PROX1 (red) with ab101851. Green - CD31, lv - large vessel, arrows - blood vessels, sg - sympathetic ganglion.

Anti-PROX1 antibody - ab104629 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PROX1 antibody (ab104629) at 1/500 dilutionLane 1 : A431 cell extract with PROX1 blocking peptideLane 2 : A431 cell extract

Anti-PROX1 antibody - ab57746 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PROX1 antibody [5G10] - ab33219 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5G10
All lanes : Anti-PROX1 antibody [5G10] (ab33219) at 10 µg/mlLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Nuclear Lysate (ab14660)Lane 2 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate (negative control)Lysates/proteins at 20 µg per lane.SecondaryGoat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PROX1 antibody [EPR3128(2)] - ab124910 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3128(2)
All lanes : Anti-PROX1 antibody [EPR3128(2)] (ab124910) at 1/1000 dilutionLane 1 : HepG2 cell lysateLane 2 : SHSY-5Y cell lysateLysates/proteins at 10 µg per lane.

Anti-PROX1 antibody - C-terminal - ab76696 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PROX1 antibody - C-terminal (ab76696) at 1/50 dilutionLane 1 : 293 cell lysateLane 2 : PROX1 transfected 293 cell lysateLysates/proteins at 2 µg per lane.

Anti-PROX1 Antibody (aa196-215) - LS-C9804 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PROX1 Antibody (aa511-527) - LS-C149012 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PROX1 Antibody (aa321-336) - LS-C149022 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PROX1 Antibody (aa2-259) - LS-C150045 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PROX1 Antibody - LS-C152954 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PROX1 Antibody (aa492-520, AP) - LS-C267174 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PROX1 Antibody (aa492-520, APC) - LS-C267175 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PROX1 Antibody (Internal, clone EPR3128(2)) - LS-C138842 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3128(2)
Western blot analysis on (A) HepG2 and (B) SH-SY5Y cell lysates using anti-PROX1 antibody.

Anti-PROX1 Antibody (aa492-520, Biotin) - LS-C267176 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PROX1 Antibody (aa144-175) - LS-C97697 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-PROX1 antibody is used in Western blot to detect PROX1 in mouse brain tissue lysate.

Anti-PROX1 Antibody (clone 5G10) - LS-C150339 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5G10
IHC of rat dentate gyrus showing specific immunolabeling of the prox1 protein. Photo courtesy of Justin Kievits and Teresa Milner, Weill Cornell Medical College.

Anti-PROX1 Antibody (aa492-520, Azide-free, HRP) - LS-C267178 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PROX1 Antibody (aa492-520, FITC) - LS-C267177 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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