| Gene Symbol |
PROX1
|
| Entrez Gene |
5629
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prospero homeobox 1
|
| Other Description |
homeobox prospero-like protein PROX1|prospero homeobox protein 1|prospero-related homeobox 1
|
| Swissprots |
Q8TB91 A6NK29 Q92786 Q5SW76 A8K2B1
|
| Accessions |
EAW93359 EAW93360 Q92786 AK025453 AK298182 BAG60453 BC024201 AAH24201 DA743374 DA802102 DB086260 EU446861 ABZ92390 U44060 AAC50656 XM_005273194 XP_005273251 XM_005273195 XP_005273252 XM_011509771 XP_011508073 XM_011509772 XP_011508074 XM_011509773 XP_011508075 XM_011509774 XP_011508076 NM_001270616 NP_001257545 NM_002763 NP_002754
|
| Function |
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization. {ECO:0000250|UniProtKB:P48437}.
|
| Tissue Specificity |
Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:8812486}.
|