Gene Symbol | Trpc6 |
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Entrez Gene | 22068 |
Alt Symbol | AV025995, LLHWJM002, LLHWJM003, LLHWJM004, TRP-6, Trrp6, mtrp6 |
Species | Mouse |
Gene Type | protein-coding |
Description | transient receptor potential cation channel, subfamily C, member 6 |
Other Description | calcium entry channel|short transient receptor potential channel 6|transient receptor protein 6 |
Swissprots | Q9Z2J1 Q61143 B9EIW2 |
Accessions | EDL24957 EDL24958 Q61143 AF057748 AAC64394 AK086446 AK133864 BAE21896 AK137447 BC067391 AAH67391 BC068310 AAH68310 BC141131 AAI41132 U49069 AAC06146 XM_006509849 XP_006509912 XM_006509850 XP_006509913 XM_011242359 XP_011240661 XM_011242360 XP_011240662 NM_001282086 NP_001269015 NM_001282087 NP_001269016 NM_013838 NP_038866 |
Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Lung and brain. |
Top Pathways | cGMP-PKG signaling pathway |
TRPC6 CRISPR/Cas9 KO Plasmid (m) - sc-423517 from Santa Cruz Biotechnology
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TRPC6 HDR Plasmid (m) - sc-423517-HDR from Santa Cruz Biotechnology
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TRPC6 Double Nickase Plasmid (m) - sc-423517-NIC from Santa Cruz Biotechnology
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TRPC6 Double Nickase Plasmid (m2) - sc-423517-NIC-2 from Santa Cruz Biotechnology
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TRPC6 CRISPR Activation Plasmid (m) - sc-423517-ACT from Santa Cruz Biotechnology
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TRPC6 CRISPR Activation Plasmid (m2) - sc-423517-ACT-2 from Santa Cruz Biotechnology
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TRPC6 Lentiviral Activation Particles (m) - sc-423517-LAC from Santa Cruz Biotechnology
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TRPC6 Lentiviral Activation Particles (m2) - sc-423517-LAC-2 from Santa Cruz Biotechnology
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TRPC6 siRNA (m) - sc-42673 from Santa Cruz Biotechnology
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TRPC6 shRNA Plasmid (m) - sc-42673-SH from Santa Cruz Biotechnology
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TRPC6 shRNA (m) Lentiviral Particles - sc-42673-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN43531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43531 from Sigma-Aldrich
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TRPC6 siRNA (Mouse) - CRM4255 from Cohesion Biosciences
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TRPC6 - MBS8216876 from MyBioSource
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shRNA set against Mouse TRPC6 (NM_013838.2) - SHH435600 from Creative biogene
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shRNA set against Mouse Trpc6(NM_013838.2) - SHL097022 from Creative biogene
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TRPC6 shRNA Plasmid (Mouse) - CHM4255 from Cohesion Biosciences
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TRPC6 miRNA 3'UTR clone - MiUTR1M-12185 from Creative biogene
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