| Gene Symbol |
Trpc6
|
| Entrez Gene |
22068
|
| Alt Symbol |
AV025995, LLHWJM002, LLHWJM003, LLHWJM004, TRP-6, Trrp6, mtrp6
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily C, member 6
|
| Other Description |
calcium entry channel|short transient receptor potential channel 6|transient receptor protein 6
|
| Swissprots |
Q9Z2J1 Q61143 B9EIW2
|
| Accessions |
EDL24957 EDL24958 Q61143 AF057748 AAC64394 AK086446 AK133864 BAE21896 AK137447 BC067391 AAH67391 BC068310 AAH68310 BC141131 AAI41132 U49069 AAC06146 XM_006509849 XP_006509912 XM_006509850 XP_006509913 XM_011242359 XP_011240661 XM_011242360 XP_011240662 NM_001282086 NP_001269015 NM_001282087 NP_001269016 NM_013838 NP_038866
|
| Function |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Lung and brain.
|
| Top Pathways |
cGMP-PKG signaling pathway
|