PTPN22

Gene Symbol PTPN22
Entrez Gene 26191
Alt Symbol LYP, LYP1, LYP2, PEP, PTPN8
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Other Description PEST-domain phosphatase|hematopoietic cell protein-tyrosine phosphatase 70Z-PEP|lymphoid phosphatase|lymphoid-specific protein tyrosine phosphatase|protein tyrosine phosphatase, non-receptor type 8|tyrosine-protein phosphatase non-receptor type 22
Swissprots Q6IPX8 E9PLD8 E9PPI1 Q9Y2R2 D4NZ71 A0N0K6 Q8WVM1 O95063 O95064 B1ALC8
Accessions ABK41897 EAW56573 EAW56574 EAW56575 EAW56576 Q9Y2R2 AA836401 AF001846 AAD00904 AF077031 AAD27764 AF150732 AAF67472 AK303124 BAG64230 AK310570 AK310698 BC017785 AAH17785 BC071670 AAH71670 CD692658 DB145424 DN997966 GU479452 ADD59979 JN084012 AEL79472 U69700 AAB09079 XM_005270738 XP_005270795 XM_011541221 XP_011539523 XM_011541222 XP_011539524 XM_011541223 XP_011539525 XM_011541224 XP_011539526 XM_011541225 XP_011539527 NM_001193431 NP_001180360 NM_001308297 NP_001295226 NM_012411 NP_036543 NM_015967 NP_057051
Function Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr- 493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro- inflammatory cytokine secretion and autophagy (PubMed:23991106). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|Pub
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. {ECO:0000269|PubMed:15208781}.

PTP22 CRISPR/Cas9 KO Plasmid (h) - sc-416917 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTP22 HDR Plasmid (h) - sc-416917-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTP22 Double Nickase Plasmid (h) - sc-416917-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTP22 Double Nickase Plasmid (h2) - sc-416917-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTP22 CRISPR Activation Plasmid (h) - sc-416917-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTP22 CRISPR Activation Plasmid (h2) - sc-416917-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTP22 Lentiviral Activation Particles (h) - sc-416917-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTP22 Lentiviral Activation Particles (h2) - sc-416917-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PTP22 siRNA (h) - sc-61419 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PTP22 shRNA Plasmid (h) - sc-61419-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PTP22 shRNA (h) Lentiviral Particles - sc-61419-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Lyp/PTPN22 RNAi - H00026191-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
RNAi sequence position: Lyp/PTPN22 RNAi [H00026191-R01V]

Lyp/PTPN22 RNAi - H00026191-R06 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU088211 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0755 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0754 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1088 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0756 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1089 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1087 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN2410 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2410 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08229 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08229

PTPN22 siRNA (Human) - CRH8753 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Lyp/PTPN22 RNAi - H00026191-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
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