PTPN22

Gene Symbol PTPN22
Entrez Gene 26191
Alt Symbol LYP, LYP1, LYP2, PEP, PTPN8
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Other Description PEST-domain phosphatase|hematopoietic cell protein-tyrosine phosphatase 70Z-PEP|lymphoid phosphatase|lymphoid-specific protein tyrosine phosphatase|protein tyrosine phosphatase, non-receptor type 8|tyrosine-protein phosphatase non-receptor type 22
Swissprots Q6IPX8 E9PLD8 E9PPI1 Q9Y2R2 D4NZ71 A0N0K6 Q8WVM1 O95063 O95064 B1ALC8
Accessions ABK41897 EAW56573 EAW56574 EAW56575 EAW56576 Q9Y2R2 AA836401 AF001846 AAD00904 AF077031 AAD27764 AF150732 AAF67472 AK303124 BAG64230 AK310570 AK310698 BC017785 AAH17785 BC071670 AAH71670 CD692658 DB145424 DN997966 GU479452 ADD59979 JN084012 AEL79472 U69700 AAB09079 XM_005270738 XP_005270795 XM_011541221 XP_011539523 XM_011541222 XP_011539524 XM_011541223 XP_011539525 XM_011541224 XP_011539526 XM_011541225 XP_011539527 NM_001193431 NP_001180360 NM_001308297 NP_001295226 NM_012411 NP_036543 NM_015967 NP_057051
Function Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr- 493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro- inflammatory cytokine secretion and autophagy (PubMed:23991106). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|Pub
Subcellular Location Cytoplasm {ECO:0000250}.
Tissue Specificity Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. {ECO:0000269|PubMed:15208781}.

PTPN22 (D6D1H) Rabbit mAb - 14693 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6D1H
Western blot analysis of extracts from various cell lines using PTPN22 (D6D1H) Rabbit mAb.

PTPN22 Antibody - 12447 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

PTP22 (E-5) - sc-393766 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PTP22 (E-5): sc-393766. Western blot analysis of PTP22 expression in Jurkat (A), U-698-M (B) and NCI-H460 (C) whole cell lysates.

PTP22 (H-253) - sc-134782 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PTP22 (H-253): sc-134782. Western blot analysis of PTP22 expression in HEK293 (A) and U-698-M (B) whole cell lysates.

PTP22 (T-16) - sc-48922 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PTP22 (T-16): sc-48922. Western blot analysis of PTP22 expression in non-transfected: sc-117752 (A) and human PTP22 transfected: sc-117396 (B) 293T whole cell lysates.

PTP22 (C-20) - sc-48920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PTP22 (C-20) : sc-48920. Western blot analysis of PTP22 expression in Jurkat whole cell lysate.

Anti-PTPN22 antibody - ab118430 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab118430 at 7.5ug/ml staining PTPN22 in Formalin-fixed, Paraffin-embedded Human adrenal tissue by Immunohistochemistry.

Anti-PTPN22 antibody - ab129936 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PTPN22 antibody (ab129936) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-PTPN22 antibody - ab169040 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PTPN22 antibody (ab169040) at 1 µg/mlLane 1 : PTPN22 transfected 293T cell lysateLane 2 : non transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-mouse HRP conjugated antibody at 1/2500 dilutiondeveloped using the ECL technique

Anti-PTPN22 antibody - N-terminal - ab157135 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-PTPN22 antibody - N-terminal (ab157135) at 1/1000 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extract

Anti-PTPN22 / PEP Antibody (aa767-781) - LS-C3104 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (aa311-325) - LS-C3105 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (aa662-691, APC) - LS-C217044 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (aa662-691, Biotin) - LS-C217046 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (aa662-691, AP) - LS-C217045 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (aa662-691, FITC) - LS-C217047 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (aa662-691, Azide-free, HRP) - LS-C217048 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (aa662-691, PE) - LS-C217049 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (aa165-704) - LS-C311559 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (aa1-153) - LS-C311811 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (aa662-691) - LS-C330040 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PTPN22 / PEP Antibody (clone 1A6) IHC-plus™ - LS-B6396 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1A6
Anti-PTPN22 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6396 concentration 5 ug/ml.

Anti-PTPN22 / PEP Antibody - LS-C192963 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of Jurkat cell lines, using PTPN22 antibody.

Anti-PTPN22 / PEP Antibody (aa662-691) - LS-C162305 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PTPN22 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The PTPN22 antibody detected the PTPN22 protein (arrow).

Anti-PTPN22 / PEP Antibody (aa361-410) - LS-C205805 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PTPN22 / PEP antibody Western Blot of Thyroid Tumor. Antibody dilution: 1 ug/ml.
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