| Gene Symbol |
PTPN22
|
| Entrez Gene |
26191
|
| Alt Symbol |
LYP, LYP1, LYP2, PEP, PTPN8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
|
| Other Description |
PEST-domain phosphatase|hematopoietic cell protein-tyrosine phosphatase 70Z-PEP|lymphoid phosphatase|lymphoid-specific protein tyrosine phosphatase|protein tyrosine phosphatase, non-receptor type 8|tyrosine-protein phosphatase non-receptor type 22
|
| Swissprots |
Q6IPX8 E9PLD8 E9PPI1 Q9Y2R2 D4NZ71 A0N0K6 Q8WVM1 O95063 O95064 B1ALC8
|
| Accessions |
ABK41897 EAW56573 EAW56574 EAW56575 EAW56576 Q9Y2R2 AA836401 AF001846 AAD00904 AF077031 AAD27764 AF150732 AAF67472 AK303124 BAG64230 AK310570 AK310698 BC017785 AAH17785 BC071670 AAH71670 CD692658 DB145424 DN997966 GU479452 ADD59979 JN084012 AEL79472 U69700 AAB09079 XM_005270738 XP_005270795 XM_011541221 XP_011539523 XM_011541222 XP_011539524 XM_011541223 XP_011539525 XM_011541224 XP_011539526 XM_011541225 XP_011539527 NM_001193431 NP_001180360 NM_001308297 NP_001295226 NM_012411 NP_036543 NM_015967 NP_057051
|
| Function |
Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr- 493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro- inflammatory cytokine secretion and autophagy (PubMed:23991106). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|Pub
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. {ECO:0000269|PubMed:15208781}.
|