PSMC3IP

Gene Symbol PSMC3IP
Entrez Gene 29893
Alt Symbol GT198, HOP2, HUMGT198A, ODG3, TBPIP
Species Human
Gene Type protein-coding
Description PSMC3 interacting protein
Other Description DBD-interacting|TBP-1-interacting protein|homologous-pairing protein 2 homolog|nuclear receptor coactivator GT198|proteasome 26S ATPase subunit 3-interacting protein|tat-binding protein 1-interacting protein
Swissprots Q8WXG2 Q14458 C5ILB7 Q9P2W1 Q96HA2
Accessions EAW60846 EAW60847 EAW60848 EAW60849 EAW60850 Q9P2W1 AB030304 BAA92872 AF440240 AAL33609 AK126369 BC008792 AAH08792 BI115923 DB494067 FJ952179 ACR46654 FJ952180 ACR46655 FJ952181 ACR46656 FJ952182 ACR46657 FJ952183 ACR46658 GQ851964 ACX30903 GQ851965 ACX30904 U18921 NM_001256014 NP_001242943 NM_001256015 NP_001242944 NM_001256016 NP_001242945 NM_013290 NP_037422 NM_016556 NP_057640 NR_045669 NR_045670 NR_045671
Function Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. {ECO:0000269|PubMed:10806355, ECO:0000269|PubMed:16407260, ECO:0000269|PubMed:21963259}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11739747}.
Tissue Specificity Highly expressed in testis and colon. {ECO:0000269|PubMed:11739747, ECO:0000269|PubMed:7490091}.

TBPIP CRISPR/Cas9 KO Plasmid (h) - sc-412041 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TBPIP HDR Plasmid (h) - sc-412041-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TBPIP Double Nickase Plasmid (h) - sc-412041-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TBPIP Double Nickase Plasmid (h2) - sc-412041-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TBPIP CRISPR Activation Plasmid (h) - sc-412041-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TBPIP CRISPR Activation Plasmid (h2) - sc-412041-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TBPIP Lentiviral Activation Particles (h) - sc-412041-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TBPIP Lentiviral Activation Particles (h2) - sc-412041-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TBPIP siRNA (h) - sc-93606 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TBPIP shRNA Plasmid (h) - sc-93606-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TBPIP shRNA (h) Lentiviral Particles - sc-93606-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU114291 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17610 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17610 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05572 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05572

PSMC3IP siRNA (Human) - CRH9252 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PSMC3IP (NM_013290.6) - SHH385300 from Creative biogene

Category siRNA
Species Reactivities Human

PSMC3IP shRNA Plasmid (Human) - CHH9252 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PSMC3IP miRNA 3'UTR clone - MiUTR4H-TG07155 from Creative biogene

Species Reactivities Human
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