| Gene Symbol |
PSMC3IP
|
| Entrez Gene |
29893
|
| Alt Symbol |
GT198, HOP2, HUMGT198A, ODG3, TBPIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PSMC3 interacting protein
|
| Other Description |
DBD-interacting|TBP-1-interacting protein|homologous-pairing protein 2 homolog|nuclear receptor coactivator GT198|proteasome 26S ATPase subunit 3-interacting protein|tat-binding protein 1-interacting protein
|
| Swissprots |
Q8WXG2 Q14458 C5ILB7 Q9P2W1 Q96HA2
|
| Accessions |
EAW60846 EAW60847 EAW60848 EAW60849 EAW60850 Q9P2W1 AB030304 BAA92872 AF440240 AAL33609 AK126369 BC008792 AAH08792 BI115923 DB494067 FJ952179 ACR46654 FJ952180 ACR46655 FJ952181 ACR46656 FJ952182 ACR46657 FJ952183 ACR46658 GQ851964 ACX30903 GQ851965 ACX30904 U18921 NM_001256014 NP_001242943 NM_001256015 NP_001242944 NM_001256016 NP_001242945 NM_013290 NP_037422 NM_016556 NP_057640 NR_045669 NR_045670 NR_045671
|
| Function |
Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. {ECO:0000269|PubMed:10806355, ECO:0000269|PubMed:16407260, ECO:0000269|PubMed:21963259}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11739747}.
|
| Tissue Specificity |
Highly expressed in testis and colon. {ECO:0000269|PubMed:11739747, ECO:0000269|PubMed:7490091}.
|