VPRBP

Gene Symbol	VPRBP
Entrez Gene	9730
Alt Symbol	DCAF1
Species	Human
Gene Type	protein-coding
Description	Vpr (HIV-1) binding protein
Other Description	DDB1 and CUL4 associated factor 1|DDB1- and CUL4-associated factor 1|HIV-1 Vpr-binding protein|Vpr-binding protein|protein VPRBP|serine/threonine-protein kinase VPRBP|vpr-interacting protein
Swissprots	Q9HCA1 Q8TBD9 Q2YD74 Q9Y4B6 Q9UG37
Accessions	EAW65140 EAW65141 EAW65142 EAW65143 Q9Y4B6 AB018343 BAA34520 AF061935 AAG27134 AF086402 AK023239 BAG51173 AL080145 CAB45738 BC022792 AAH22792 BC110371 AAI10372 BP222559 CR986856 XM_005276753 XP_005276810 XM_005276755 XP_005276812 XM_006713428 XP_006713491 XM_011534273 XP_011532575 XM_011534274 XP_011532576 XM_011534275 XP_011532577 XM_011534276 XP_011532578 XM_011534277 XP_011532579 XM_011534278 XP_011532580 XM_011534279 XP_011532581 XM_011534280 XP_011532582 XR_940521 XR_940522 XR_940523 XR_940524 XR_940525 NM_001171904 NP_001165375 NM_014703 NP_055518
Function	Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1- DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT
Subcellular Location	Cytoplasm. Nucleus. Note=Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11223251}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® VPRBP siRNA I - 14010 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

VPRBP CRISPR/Cas9 KO Plasmid (h) - sc-403283 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VPRBP HDR Plasmid (h) - sc-403283-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VPRBP Double Nickase Plasmid (h) - sc-403283-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VPRBP Double Nickase Plasmid (h2) - sc-403283-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VPRBP CRISPR Activation Plasmid (h) - sc-403283-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VPRBP CRISPR Activation Plasmid (h2) - sc-403283-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VPRBP Lentiviral Activation Particles (h) - sc-403283-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VPRBP Lentiviral Activation Particles (h2) - sc-403283-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VPRBP siRNA (h) - sc-76898 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

VPRBP shRNA Plasmid (h) - sc-76898-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

VPRBP shRNA (h) Lentiviral Particles - sc-76898-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU133551 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22702 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22702 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08703 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08703

VPRBP siRNA (Human) - CRH6498 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

VPRBP - MBS8205998 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human VPRBP (NM_014703.2) - SHH444728 from Creative biogene Category siRNA Species Reactivities Human

VPRBP shRNA Plasmid (Human) - CHH6498 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

VPRBP miRNA 3'UTR clone - MiUTR3H-16534 from Creative biogene Species Reactivities Human

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