| Gene Symbol |
VPRBP
|
| Entrez Gene |
9730
|
| Alt Symbol |
DCAF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Vpr (HIV-1) binding protein
|
| Other Description |
DDB1 and CUL4 associated factor 1|DDB1- and CUL4-associated factor 1|HIV-1 Vpr-binding protein|Vpr-binding protein|protein VPRBP|serine/threonine-protein kinase VPRBP|vpr-interacting protein
|
| Swissprots |
Q9HCA1 Q8TBD9 Q2YD74 Q9Y4B6 Q9UG37
|
| Accessions |
EAW65140 EAW65141 EAW65142 EAW65143 Q9Y4B6 AB018343 BAA34520 AF061935 AAG27134 AF086402 AK023239 BAG51173 AL080145 CAB45738 BC022792 AAH22792 BC110371 AAI10372 BP222559 CR986856 XM_005276753 XP_005276810 XM_005276755 XP_005276812 XM_006713428 XP_006713491 XM_011534273 XP_011532575 XM_011534274 XP_011532576 XM_011534275 XP_011532577 XM_011534276 XP_011532578 XM_011534277 XP_011532579 XM_011534278 XP_011532580 XM_011534279 XP_011532581 XM_011534280 XP_011532582 XR_940521 XR_940522 XR_940523 XR_940524 XR_940525 NM_001171904 NP_001165375 NM_014703 NP_055518
|
| Function |
Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1- DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11223251}.
|