| Gene Symbol |
CNP
|
| Entrez Gene |
280752
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
2',3'-cyclic nucleotide 3' phosphodiesterase
|
| Other Description |
2',3'-cyclic-nucleotide 3'-phosphodiesterase|CNPase
|
| Swissprots |
Q3SZJ6 P06623
|
| Accessions |
DAA18417 P06623 BC102820 AAI02821 J02659 AAA30456 M27606 AAA30457 Y00405 CAA68466 XM_005220661 XP_005220718 XM_005220662 XP_005220719 XM_010816213 XP_010814515 NM_180993 NP_851336
|
| Function |
May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. {ECO:0000250}.
|
| Subcellular Location |
Membrane; Lipid-anchor. Melanosome {ECO:0000250}. Note=Firmly bound to membrane structures of brain white matter.
|
![Overlay histogram showing SHSY-5Y cells stained with ab80789 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab80789, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SHSY-5Y cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_2/147_ab80789-3-ab80789FC.jpg)
