Gene Symbol | ARAP2 |
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Entrez Gene | 116984 |
Alt Symbol | CENTD1, PARX |
Species | Human |
Gene Type | protein-coding |
Description | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Other Description | Arf and Rho GAP adapter protein 2|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2|centaurin, delta 1|centaurin-delta-1|cnt-d1 |
Swissprots | Q96P49 Q96L70 Q9Y4E4 Q7Z2L5 Q4W5D2 Q8WZ64 |
Accessions | AAY40927 EAW92870 EAW92871 EAW92872 Q8WZ64 AB011152 BAA25506 AF411982 AAL04166 AF439781 AAL32459 AK126864 AW274408 AY049733 AAL12170 BC105089 AAI05090 BC105091 AAI05092 BC150258 AAI50259 BC160097 AAI60097 BX104334 XM_005262642 XP_005262699 NM_015230 NP_056045 NM_139182 |
Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11804590}. |
Top Pathways | Endocytosis |
ARAP2 CRISPR/Cas9 KO Plasmid (h) - sc-407500 from Santa Cruz Biotechnology
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ARAP2 HDR Plasmid (h) - sc-407500-HDR from Santa Cruz Biotechnology
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ARAP2 Double Nickase Plasmid (h) - sc-407500-NIC from Santa Cruz Biotechnology
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ARAP2 Double Nickase Plasmid (h2) - sc-407500-NIC-2 from Santa Cruz Biotechnology
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ARAP2 CRISPR Activation Plasmid (h) - sc-407500-ACT from Santa Cruz Biotechnology
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ARAP2 CRISPR Activation Plasmid (h2) - sc-407500-ACT-2 from Santa Cruz Biotechnology
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ARAP2 Lentiviral Activation Particles (h) - sc-407500-LAC from Santa Cruz Biotechnology
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ARAP2 Lentiviral Activation Particles (h2) - sc-407500-LAC-2 from Santa Cruz Biotechnology
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ARAP2 siRNA (h) - sc-60198 from Santa Cruz Biotechnology
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ARAP2 shRNA Plasmid (h) - sc-60198-SH from Santa Cruz Biotechnology
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ARAP2 shRNA (h) Lentiviral Particles - sc-60198-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU019741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3382 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3382 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10576 from Sigma-Aldrich
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ARAP2 siRNA (Human) - CRJ4542 from Cohesion Biosciences
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ARAP2 - MBS8235024 from MyBioSource
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shRNA set against Human ARAP2 (NM_015230.3) - SHH239002 from Creative biogene
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Human ARAP2 siRNA - orb275043 from Biorbyt
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ARAP2 shRNA Plasmid (Human) - CHJ4542 from Cohesion Biosciences
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ARAP2 miRNA 3'UTR clone - MiUTR3H-08629 from Creative biogene
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