| Gene Symbol |
ARAP2
|
| Entrez Gene |
116984
|
| Alt Symbol |
CENTD1, PARX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
|
| Other Description |
Arf and Rho GAP adapter protein 2|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2|centaurin, delta 1|centaurin-delta-1|cnt-d1
|
| Swissprots |
Q96P49 Q96L70 Q9Y4E4 Q7Z2L5 Q4W5D2 Q8WZ64
|
| Accessions |
AAY40927 EAW92870 EAW92871 EAW92872 Q8WZ64 AB011152 BAA25506 AF411982 AAL04166 AF439781 AAL32459 AK126864 AW274408 AY049733 AAL12170 BC105089 AAI05090 BC105091 AAI05092 BC150258 AAI50259 BC160097 AAI60097 BX104334 XM_005262642 XP_005262699 NM_015230 NP_056045 NM_139182
|
| Function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11804590}.
|
| Top Pathways |
Endocytosis
|