IL33

Gene Symbol IL33
Entrez Gene 403810
Alt Symbol DVS27
Species Dog
Gene Type protein-coding
Description interleukin 33
Other Description IL-33|interleukin-33
Swissprots O97863
Accessions O97863 AB024517 BAA75891 XM_005626370 XP_005626427 NM_001003180 NP_001003180
Function Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10566975}. Chromosome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in cultured umbilical artery smooth muscle cells after stimulation with IL1A and IL1B, and to a lesser extent with IFNG. Expressed in vasospastic cerebral arteries after subarachnoid hemorrhage. {ECO:0000269|PubMed:10566975}.
Top Pathways Cytosolic DNA-sensing pathway, Influenza A

Canine IL 33 protein - orb139198 from Biorbyt

Category Protein
Prices $162.00, $400.00, $1,224.00
Sizes 5 μg, 20 μg, 100 μg
Source E. coli
SDS-PAGE analysis of Canine IL33 protein (Native)

Canine IL33 / Interleukin-33 / NF-HEV Protein - 70005-DNAE-5 from Sino Biological

Category Protein
Prices $78.00, $178.00, $698.00
Sizes 5 µg, 20 µg, 100 µg
Source E. coli
Species Dog

Recombinant Dog Interleukin-33(IL33) - CSB-YP011656DO CSB-EP011656DO CSB-BP011656DO CSB-MP011656DO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Dog

Canine IL33 / Interleukin-33 / NF-HEV Protein - 70005-DNAE from ABclonal

Category Protein
Prices $78.00, $178.00, $698.00
Sizes 5 µg, 20 µg, 100 µg
Source E. coli
Species Dog

Interleukin-33 (IL33), Recombinant Protein - MBS1214277 from MyBioSource

Category Protein
Prices $895.00, $895.00, $1,120.00, $1,120.00, $1,320.00, $1,320.00, $1,775.00, $1,775.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Dog
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