| Gene Symbol | IL33 |
|---|---|
| Entrez Gene | 403810 |
| Alt Symbol | DVS27 |
| Species | Dog |
| Gene Type | protein-coding |
| Description | interleukin 33 |
| Other Description | IL-33|interleukin-33 |
| Swissprots | O97863 |
| Accessions | O97863 AB024517 BAA75891 XM_005626370 XP_005626427 NM_001003180 NP_001003180 |
| Function | Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10566975}. Chromosome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed in cultured umbilical artery smooth muscle cells after stimulation with IL1A and IL1B, and to a lesser extent with IFNG. Expressed in vasospastic cerebral arteries after subarachnoid hemorrhage. {ECO:0000269|PubMed:10566975}. |
| Top Pathways | Cytosolic DNA-sensing pathway, Influenza A |