HES1

Gene Symbol	HES1
Entrez Gene	3280
Alt Symbol	HES-1, HHL, HRY, bHLHb39
Species	Human
Gene Type	protein-coding
Description	hes family bHLH transcription factor 1
Other Description	class B basic helix-loop-helix protein 39|hairy homolog|hairy-like protein|transcription factor HES-1
Swissprots	Q14469 Q6FHB2
Accessions	AAA65220 EAW78058 Q14469 AF264785 AAF73060 AI370424 AK000415 BAA91149 AK300482 BAG62198 BC005178 AAH05178 BC039152 AAH39152 BC156516 AAI56517 BC172546 AAI72546 CR541843 CAG46641 DQ891328 ABM82254 DQ893354 ABM84280 DQ896673 ABM87672 DW424342 NM_005524 NP_005515
Function	Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}.
Subcellular Location	Nucleus.
Top Pathways	Notch signaling pathway, Maturity onset diabetes of the young, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Hes1 peptide - ab126460 from Abcam Category Peptide Prices $285.00 Sizes 50 µg

Human Hes1 full length protein - ab152460 from Abcam Category Protein Source Wheat germ Species Human

Human Hes1 protein fragment - ab112302 from Abcam Category Protein Source Wheat germ Species Human

Human Hes1 protein fragment - ab114192 from Abcam Category Protein Source Wheat germ Species Human

HES1-Antibody-N-term-Blocking-peptide - BP14023a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HES1-Antibody-N-term-T24-Blocking-Peptide - BP6276a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HES1 - H00003280-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

HES1 - H00003280-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

HES1 - H00003280-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

HES1 - H00003280-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

HES1 - H00003280-Q03 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

HES1 - H00003280-Q03-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

HES1 - H00003280-Q03-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Recombinant Human HES1 - HES1-26539TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human HES1 - HES1-27078TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human HES1, His-tagged - HES1-289H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Hairy And Enhancer Of Split 1 (HES1) - RPK289Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Transcription factor HES-1 peptide - pep0355 from Covalab Category Peptide Species Human, Mouse, Rat

Recombinant Human Transcription factor HES-1(HES1) - CSB-YP622769HU CSB-EP622769HU CSB-BP622769HU CSB-MP622769HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HES1 Peptide - abx165225 from Abbexa Category Peptide Species Human, Mouse, Rat

HES1 - TP311709 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

HES1 (N-term HIS tag) - TP760671 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

HES1-Blocking-Peptide-C-term - BP21002c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HES1-Blocking-Peptide-C-term - BP21428b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HES1 Recombinant Protein (OPCD03842) - OPCD03842 from Aviva Systems Biology Category Protein Source E.coli Species Human

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