ACSL5

Gene Symbol ACSL5
Entrez Gene 51703
Alt Symbol ACS2, ACS5, FACL5
Species Human
Gene Type protein-coding
Description acyl-CoA synthetase long-chain family member 5
Other Description FACL5 for fatty acid coenzyme A ligase 5|LACS 5|fatty acid coenzyme A ligase 5|fatty-acid-Coenzyme A ligase, long-chain 5|long-chain acyl-CoA synthetase 5|long-chain fatty acid coenzyme A ligase 5|long-chain-fatty-acid--CoA ligase 5
Swissprots Q9UIU4 D3DRB3 Q6UX44 A6GV77 Q9ULC5
Accessions BAA86054 CAC79123 CAJ56749 EAW49532 EAW49533 EAW49534 EAW49535 EAW49536 EAW49537 EAW49538 EAW49539 Q9ULC5 AB033899 BAA85979 AJ496489 CAD43000 AK000339 AK024932 AK222782 AK223288 AK301786 BAG63242 AK310436 AL708480 AM262166 CAK18174 AY358520 AAQ88884 BC007985 AAH07985 CD689921 CF595490 DQ893266 ABM84192 DQ896596 ABM87595 NM_016234 NP_057318 NM_203379 NP_976313 NM_203380 NP_976314
Function Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:18806831, ECO:0000269|PubMed:19459852}.
Subcellular Location Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Top Pathways Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation

ACSL5 (E-12) - sc-398310 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACSL5 (E-12): sc-398310. Western blot analysis of ACSL5 expression in HeLa (A), Hep G2 (B) and MDA-MB-231 (C) whole cell lysates and human placenta (D), human spleen (E) and human liver (F) tissue extracts.

ACSL5 (A-2) - sc-365478 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACSL5 (A-2): sc-365478. Western blot analysis of ACSL5 expression in Hep G2 whole cell lysate.

ACSL5 (C-16) - sc-47999 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACSL5 (C-16): sc-47999. Western blot analysis of ACSL5 expression in Hep G2 whole cell lysate.

ACSL5 (H-41) - sc-134508 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ACSL5 (N-17) - sc-48002 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACSL5 (N-17): sc-48002. Western blot analysis of ACSL5 expression in non-transfected: sc-117752 (A) and mouse ACSL5 transfected: sc-118222 (B) 293T whole cell lysates.

Anti-ACSL5 antibody - ab57210 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HepG2 cells stained with ab57210 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab57210, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-ACSL5 antibody - ab104892 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ACSL5 antibody (ab104892) at 1 µg/ml + Human placenta lysate at 10 µgGel concentration 12%

Anti-ACSL5 antibody - ab115526 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115526 at 2.5ug/ml staining ACSL5 in Formalin-fixed, Paraffin-embedded Human small intestine tissue by followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-ACSL5 antibody - ab48035 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-ACSL5 antibody (ab48035) at 1 µg/ml + Human Spleen lysate (35&microg protein in RIPA buffer).

Anti-ACSL5 antibody - ab172576 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ACSL5 antibody (ab172576) at 1 µg/mlLane 1 : ACSL5 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Rabbit IgG (H+L), peroxidase conjugate at 1/7500 dilutiondeveloped using the ECL technique

Anti-ACSL5 antibody - C-terminal - ab188507 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ACSL5 antibody - C-terminal (ab188507) at 1/500 dilution + mouse brain lysate

Anti-ACS5 / ACSL5 Antibody (clone 5H8) - LS-C133760 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5H8
Immunoperoxidase of monoclonal antibody to ACSL5 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml]

Anti-ACS5 / ACSL5 Antibody (aa470-519) IHC-plus™ - LS-B5798 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ACSL5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5798 concentration 5 ug/ml.

Anti-ACS5 / ACSL5 Antibody (aa727-739) IHC-plus™ - LS-B2761 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-ACSL5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2761 concentration 5 ug/ml.

Anti-ACS5 / ACSL5 Antibody - LS-C306066 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ACS5 / ACSL5 Antibody - LS-C309308 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ACS5 / ACSL5 Antibody - LS-C335145 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of mouse brain tissue lines, using ACSL5 antibody.

ACSL5 Antibody - NBP1-59645 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ACSL5 Antibody [NBP1-59645] - Detection of ACSL5 in rat lysate. Image provided by Dr. Eric Klett of UNC School of Medicine.

ACSL5 Antibody (5H8) - H00051703-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5H8

ACSL5 Antibody - NBP2-31995 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ACSL5 Antibody [NBP2-31995] - Analysis in human cell line CAPAN-2.

ACSL5 Antibody - H00051703-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: ACSL5 Antibody [H00051703-B01] - Western Blot analysis of ACSL5 expression in human liver.

ACSL5 Antibody - NB100-2918 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: ACSL5 Antibody [NB100-2918] - Analysis of ACSL5 using NB100-2918 at 1ug/ml in Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

ACSL5 Antibody - H00051703-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: ACSL5 Antibody [H00051703-D01P] - Analysis of ACSL5 expression in transfected 293T cell line by ACSL5 polyclonal antibody.Lane 1: ACSL5 transfected lysate(82.30 KDa).Lane 2: Non-transfected lysate.

ACSL5 Antibody - H00051703-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

ACSL5 Antibody - H00051703-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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