SMC1A

Gene Symbol	SMC1A
Entrez Gene	8243
Alt Symbol	CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Species	Human
Gene Type	protein-coding
Description	structural maintenance of chromosomes 1A
Other Description	SMC protein 1A|SMC-1-alpha|SMC1 (structural maintenance of chromosomes 1, yeast)-like 1|segregation of mitotic chromosomes 1|structural maintenance of chromosomes protein 1A
Swissprots	Q16351 Q2M228 O14995 Q14683
Accessions	CAI42089 CAI42645 CAI42646 EAW93149 EAW93150 EAW93151 Q14683 AF176781 AAQ13659 AK055575 AK056308 AK091458 AK291921 BAF84610 AK301266 BAH13445 BC064368 AAH64368 BC080185 AAH80185 BC112127 AAI12128 BC171726 BP312805 BQ232418 BX640922 CAE45960 D80000 BAA11495 HQ258690 ADR83441 S78271 AAB34405 NM_001281463 NP_001268392 NM_006306 NP_006297
Function	Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12199140}. Chromosome {ECO:0000269|PubMed:12199140}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12199140}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere- kinetochore complex at the kinetochore region during mitosis.
Top Pathways	Cell cycle, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SMC1A protein fragment - ab159978 from Abcam Category Protein Source Wheat germ Species Human

SMC1A / SMC1 Antibody Blocking Peptide - LS-E2509 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMC1A / SMC1 Antibody Blocking Peptide - LS-E13962 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SMC1 Protein - H00008243-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SMC1A-Antibody-N-term-Blocking-peptide - BP13544a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMC1A Blocking Peptide - 33R-9611 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SMC1A / SMC1 - H00008243-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMC1A / SMC1 - H00008243-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMC1A fusion protein - Ag16286 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SMC1A fusion protein - ag17257 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SMC1 (Phospho-Ser957) Antibody Blocking Peptide - GWB-CA176C from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

Recombinant Human SMC1A, GST-tagged - SMC1A-2808H from Creative Biomart Category Protein Source E.coli Species Human

SMC 1 (S951) Peptide - BS1326P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-SMC 1 (S957) Peptide - BS4174P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Structural maintenance of chromosomes protein 1A(SMC1A) ,partial - CSB-YP614804HU CSB-EP614804HU CSB-BP614804HU CSB-MP614804HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SMC1(Phospho-Ser957) antibody blocking peptide - 51198 from Signalway Antibody Category Peptide Prices $70.00 Sizes 100 µl

SMC1 Protein - NBP1-84955PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SMC1 (pSer957) Blocking Peptide (OESA09481) - OESA09481 from Aviva Systems Biology Category Peptide Prices $245.00 Sizes 50 µg Species Human

SMC1 (pSer966) Blocking Peptide (OESA09482) - OESA09482 from Aviva Systems Biology Category Peptide Prices $245.00 Sizes 50 µg Species Human

Phospho-Smc1S957-Antibody-Blocking-peptide - BP3252a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

SMC1A Peptide, Human - M34GP14735H from Creative Peptides Category Peptide Source Synthetic. Species Human

Structural maintenance of chromosomes protein 1A (SMC1A), partial, Recombinant Protein - MBS1339136 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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