SMC1A

Gene Symbol	SMC1A
Entrez Gene	8243
Alt Symbol	CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Species	Human
Gene Type	protein-coding
Description	structural maintenance of chromosomes 1A
Other Description	SMC protein 1A|SMC-1-alpha|SMC1 (structural maintenance of chromosomes 1, yeast)-like 1|segregation of mitotic chromosomes 1|structural maintenance of chromosomes protein 1A
Swissprots	Q16351 Q2M228 O14995 Q14683
Accessions	CAI42089 CAI42645 CAI42646 EAW93149 EAW93150 EAW93151 Q14683 AF176781 AAQ13659 AK055575 AK056308 AK091458 AK291921 BAF84610 AK301266 BAH13445 BC064368 AAH64368 BC080185 AAH80185 BC112127 AAI12128 BC171726 BP312805 BQ232418 BX640922 CAE45960 D80000 BAA11495 HQ258690 ADR83441 S78271 AAB34405 NM_001281463 NP_001268392 NM_006306 NP_006297
Function	Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12199140}. Chromosome {ECO:0000269|PubMed:12199140}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12199140}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere- kinetochore complex at the kinetochore region during mitosis.
Top Pathways	Cell cycle, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMC1α CRISPR/Cas9 KO Plasmid (h) - sc-402865 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SMC1α HDR Plasmid (h) - sc-402865-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SMC1α Double Nickase Plasmid (h) - sc-402865-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SMC1α Double Nickase Plasmid (h2) - sc-402865-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SMC1α CRISPR Activation Plasmid (h) - sc-402865-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SMC1α CRISPR Activation Plasmid (h2) - sc-402865-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SMC1α Lentiviral Activation Particles (h) - sc-402865-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SMC1α Lentiviral Activation Particles (h2) - sc-402865-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SMC1α siRNA (h) - sc-38385 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SMC1α shRNA Plasmid (h) - sc-38385-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SMC1α shRNA (h) Lentiviral Particles - sc-38385-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SMC1α siRNA (h2) - sc-38387 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SMC1α shRNA Plasmid (h2) - sc-38387-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SMC1α shRNA (h2) Lentiviral Particles - sc-38387-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SMC1 RNAi - H00008243-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU074001 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® esiRNA - EHU101841 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19773 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19773 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SMC1A siRNA (Human) - CRH5413 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SMC1A - MBS8241068 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SMC1A(NM_006306.2) - SHL016266 from Creative biogene Category siRNA Species Reactivities Human

Human SMC1A siRNA - orb265915 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SMC1A shRNA Plasmid (Human) - CHH5413 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SMC1A miRNA 3'UTR clone - MiUTR1H-09652 from Creative biogene Species Reactivities Human

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